Although scurvy has become a rare disease, but vitamin C is closely related to the prevention and treatment of a variety of diseases, in recent years, more research applications are the following kinds of diseases. A, atherosclerosis 1, to prevent the occurrence of atherosclerosis on the occurrence of atherosclerosis, in recent years for the endothelial cell chemical damage; hemodynamics and immunology and other injury doctrine, has attracted the attention of many scholars. It has been reported that vitamin C deficiency not only damages capillaries, but also large arteries, and long-term sustained vitamin C deficiency can lead to atherosclerosis. hornig used radiographic autoradiography study to prove that the large artery wall contains more vitamin C. Villis reported that vitamin C deficiency can lead to lipid deposition in the inner wall of arteries, which can be seen to disappear when vitamin C is given. Many other authors have reported that hyperlipidemia caused by vitamin C deficiency is due to a decrease in endothelial lipoprotein lipase activity, resulting in a decrease in 7α-hydroxylase activity, which promotes cholesterol catabolism. Although the above-mentioned reports are mostly the results of animal experiments and do not completely explain the human situation, adequate vitamin C does have a protective effect on endothelial cells, so some authors advocate vitamin C endothelial cell protection therapy. In addition, Miasnikov’s survey of long-lived people in longevity villages showed that people with less atherosclerosis had a high intake of vitamin C. 2, inhibit the risk factor of atherosclerosis hyperlipidemia is the biggest risk factor of atherosclerosis. The vitamin C in the blood of people with hyperlipidemia also shows low values, so it is believed that increased cholesterol intake can lead to increased vitamin C needs. Ginter has recently reported that the treatment of hyperlipidemia with vitamin C and pectin is effective. Smoking is also one of the risk factors for atherosclerosis, and smoking can cause a decrease in vitamin C in the blood. Experiments have shown that 1 cigarette can cause a 0.06 mg% drop in plasma vitamin C; more than 20 cigarettes per day than non-smokers plasma vitamin C is 40% lower; its mechanism is not very clear, but there is a speculation: (1) because of nicotine stimulation of sympathetic nerves, resulting in live dopamine to norepinephrine via; (2) small intestine 5-hydroxytryptamine hyperproduction, resulting in increased consumption of vitamin C; (3) vitamin C inhibits carbon monoxide and blood pressure. (3) vitamin C inhibits the binding of carbon monoxide to hemoglobin; (4) vitamin C is used to detoxify certain toxicants produced by smoking, resulting in increased consumption. Hypertension is also a risk factor for atherosclerosis. Some authors have shown by epidemiological methods that vitamin C is low in the blood of hypertensive patients. Catecholamines are known to play an important role in the development of hypertension, and catecholamines, like smoking, are associated with the conversion of dopamine to norepinephrine via the pathway. ito give rats with naturally occurring hypertension large amounts of vitamin C, a decrease in blood pressure was seen. russek reported that stress factors are the greatest promoters of atherosclerosis, and that mental stress promotes vitamin C breakdown and a decrease in blood vitamin C. Prevention of heat stress, such as miners, is effective when vitamin C is given. When the body is under stressful conditions such as myocardial infarction, its plasma and intra-leukocyte vitamin C decreases in the acute phase, while the blood hydrocortisone rises. The formation of atherosclerosis is related to a variety of factors, and the role of vitamin C should be interpreted in many ways. (1) Prevention and control of colds Since Pauling reported that vitamin C can prevent colds, there have been various debates on its effectiveness. chalmers believes that vitamin C is effective in reducing the symptoms of colds, but has doubts about its therapeutic effect. baird reported that giving 80mg of vitamin C can reduce the symptoms of colds, and has a negative attitude towards Pauling’s high dose. In terms of reducing cold symptoms, some believe it is a direct effect on the virus; others believe it is a secondary effect through leukocytes; and others believe it is an antihistamine effect. (2) Control of inflammation Vitamin C and inflammation is mainly through the antioxidant effect of vitamin C. Andeson believes that inhibition of the myeloperoxidase/H2O2/halide lineage of leukocytes and improvement of leukocyte motility are the basis of the anti-inflammatory effect of vitamin C. Whether the effect of vitamin C on peroxidase is direct inhibition or by processing the toxic oxidation products of this enzyme lineage is not well understood. Although the antibacterial effect of vitamin C is not clear, it has been reported that vitamin C has the effect of inhibiting bacterial peroxidase, while acting as an anti-inflammatory agent via H2O2. It has also been reported that in Chediak-Higashi syndrome, administration of 200 mg of vitamin C daily normalized the increased c-AMP in leukocytes, restoring the motility of leukocytes and reducing the onset of infection. This effect on leukocyte c-AMP has been reported to be the result of increased lymphocyte activity. To the phenomenon of increased B-cell ratio and decreased T-cells presented by vitamin C deficiency; the administration of vitamin C results in the opposite change, i.e. an increase in T-cells. The relationship between vitamin C and humoral immunity is not well understood, but the increase in IgE and the decrease in leukocyte motility in patients with bronchial asthma were improved by the administration of vitamin C (1 g.d-1). In addition, the role of aspirin with vitamin C must also be taken into account. Aspirin can inhibit the absorption of vitamin C and reduce the plasma and leukocyte levels of vitamin C. This may be due to an antagonistic effect of aspirin on the active absorption of vitamin C; or an antagonistic effect of aspirin with the vitamin C receptor of the leukocyte cell membrane. It has also been reported that vitamin C has an increased effect on interferon (interferon). Experimentally, it has been demonstrated that interferon production increased when vitamin C was added to the medium of human fibroblasts or mouse fibroblasts and L cells, and its role in the organism is unknown. Third, cancer patients with increased vitamin C consumption, often with symptoms similar to scurvy. pauling with ultraviolet light irradiation of nude mice to generate flat epithelial carcinoma, the administration of vitamin C significantly lower than the control group. Environmental chemical carcinogens N-nitrosodimethylamine or N-nitrosodiethylamine can induce cancer at 10 μg.kg-1 body weight per day. Mivish reported that vitamin C has an inhibitory effect on their formation. Since then, there have been many reports that vitamin C has inhibitory effects on a variety of experimental tumors. However, Imaida and Fukushima et al. reported that administration of high doses of vitamin C had a promoting effect on BBN-induced precancerous lesions of the bladder. Murata et al, gave more than 5 g (average 25 g) of vitamin C via intravenous junction to patients with advanced cancer and the average life expectancy was significantly prolonged. About the anti-cancer effect of ground vitamin C is generally considered through the following pathways. 1.Deactivate the hyaluronidase of cancerous tissues, so that the increased connective tissue decreases and inhibits the development of cancer. 2.Inhibit phosphodiesterase by making adenylate cyclase inactive, thus can inhibit the development of cancer induced by the increase of c-AMP in tissues. 3.Immune effect on the self-defense effect of cancer. IV. Other disorders and drugs and vitamin C 1. Vitamin C is related to tyrosine metabolism. In order to prevent neonatal tyrosinemia, the Canadian Academy of Pediatrics recommends that 100 mg of vitamin C should be given to newborns. In adults, vitamin C is closely related to iron metabolism and vitamin B12 metabolism. Vitamin C can reduce Fe3+ to Fe2+ and promote the absorption of iron, so for iron deficiency anemia there is iron supplementation at the same time should be supplemented with vitamin C. 2, drugs and vitamin C in clinical applications must also pay attention to the interaction of drugs and vitamin C. As the use of anticoagulant drugs – benzylacetone coumarin, large doses of vitamin C can shorten the prothrombin element time, must pay attention to avoid and use large doses, so as not to cause bleeding. In addition women taking oral contraceptives have decreased plasma, white blood cell and platelet vitamin C levels, indicating an increased need in the body.