Chronic colitis is a chronic inflammation of the colonic mucosa, with a long course and recurring symptoms that aggravate the attack. There are many causes of chronic colitis, and treatment should be comprehensive for the cause of the disease. The causes of chronic colitis may be chronic bacterial infections, parasitic infections, allergies, drug stimulation, and non-specific colitis (including ulcerative colitis, Crohn’s disease, etc.). Identifying the cause is essential for the treatment of chronic colitis. 1, infectious colitis commonly used anti-infective drugs: according to the results of the bacterial culture selected for the causative bacteria; clear for parasites should be anti-parasitic treatment. 2, Mesalazine and other anti-inflammatory drugs; mainly used for ulcerative colitis, especially mild to moderate, or severe ulcerative colitis after the treatment of remission. 3, corticosteroids: commonly used prednisone, generally commonly used in moderate ulcerative colitis, Crohn’s disease patients. 4, probiotics: milder chronic colitis, chronic colitis without a specific diagnosis, and patients who have not found a specific pathogenic bacteria can apply such drugs. Chronic colitis belongs to the category of “chronic diarrhea” in Chinese medicine, and the location of the disease is mainly in the liver and spleen, so treatment should be based on evidence-based treatment in Chinese medicine, which varies from person to person. It is recommended to go to a regular hospital and listen to the advice of a professional Chinese medicine practitioner. In addition, during the medication period, do not eat undigested food, greasy, spicy, alcohol and tobacco, pay attention to the regular diet, eat less and more meals, work and rest regularly, do not stay up late. The best treatment for chronic colitis is a combination of medication and controlled diet.