Usually, nucleic acid testing can be done after the vaccination. However, for the accuracy of the test results and the recipient’s own reaction, it is recommended to take a break from the vaccination before performing the nucleic acid test, or at the earliest, the day after the vaccination. In addition, the vaccinees should be aware that the vaccination does not mean that they will not be infected with the New Coronavirus, so they need to protect themselves from it in their daily lives. When administering the New Coronavirus vaccine, the vaccine contents may contaminate the vaccine recipient through pre-injection exhaust and aerosols, which may affect the sampling results and thus may result in false positive nucleic acid. At the same time, although the inactivated neo-coronavirus vaccine has inactivated the virus, nucleic acid fragments of neo-coronavirus may be present in the vaccine, which in turn may cause the patient to test positive. Therefore, it is recommended that nucleic acid testing be performed the next day to avoid affecting the accuracy of the results. Some people may experience transient adverse reactions such as localized skin redness, swelling and pain, and mild discomfort such as headache, nausea and vomiting after the vaccination. These reactions may be aggravated when the nucleic acid test is performed immediately after the vaccination and the nasopharynx is irritated by the sampling swab. In summary, if you want to have a nucleic acid test after the New Crown vaccine, it is recommended that you do not do it immediately, but at least the next day. Note that the New Crown vaccine does not completely block infection, so if you have traveled to an intermediate or high-risk area or had contact with a confirmed patient in the recent past, you should actively and promptly undergo nucleic acid testing in accordance with national policy, and be isolated at home. Avoid eating, drinking, etc. for 2 hours prior to performing nucleic acid testing to avoid uncomfortable symptoms during the process of nucleic acid testing.