“The most important thing is that you will be able to get the most out of your hemorrhoids. In fact, because of the special nature of the site of hemorrhoids, many patients have pain in this area, but often have the pain to say, preferring to suffer in silence at night, rather than visit the anorectal department. On the one hand, they feel ashamed to talk about it, and on the other hand, they are afraid of having to go under the knife in that vulnerable area. But in fact, not all hemorrhoids have to undergo traditional surgery; for small bleeding internal hemorrhoids, hemorrhoid injection therapy is more suitable. The main reason for hemorrhoids is that the venous plexus in the lower part of the anal canal and rectum is congested or stagnant, which causes the plexus to swell, resulting in bleeding, pain, itching and prolapsed hemorrhoids during bowel movements. The basic principle of injection therapy is to inject drugs into the patient’s hemorrhoid tissue and surrounding tissues to produce aseptic inflammatory changes and fibrous hyperplasia, which causes adhesion and fixation of the downwardly displaced anal cushion to its surrounding tissues, strengthens the supporting tissues of the cushion, and reduces or eliminates clinical symptoms. In addition, the injected drug can lead to the destruction of some sinusoidal veins, the formation of thrombi in individual vessels and the atrophy of the hemorrhoid nucleus, reducing or eliminating clinical symptoms, which can also achieve the purpose of treatment. Hemorrhoid injection therapy is especially suitable for small bleeding internal hemorrhoids, such as simple internal hemorrhoids stage I-IV patients. It is widely used for its minimal damage, ease of operation and quick recovery, and is particularly suitable for patients taking anticoagulant drugs. Unraveling the mystery of the drugs represented by hemorrhoid injections There are two types of injections that are widely used in clinical practice: softening and shrinking agents such as Paeonibe injection, and sclerosing agents such as eliminating hemorrhoids and polyglactin. The mechanism of action of different drugs is also different. 1, softening and shrinking agent Paeoniae injection is a pure Chinese medicine preparation, based on the theory that internal hemorrhoids are “dilated by meridians and stagnant blood”, which causes the non-inflammatory protein of the submucosal vein wall to coagulate and gradually disintegrate and absorb after injection into the hemorrhoid nucleus, thus shrinking the dilated vein wall and causing the hemorrhoid nucleus to shrink. The Paeoniflora injection can effectively shrink the nucleus of hemorrhoids while also avoiding the risk of bleeding due to local congestion and erosion of the hemorrhoid mucosa after sclerotherapy injection and the scarring hardness caused by excessive tissue fibrosis, which is much safer. 2, sclerosing agent Hemorrhoid injection is commonly used to treat hemorrhoids sclerosing agent, but also the most representative injection therapy is widely carried out in China, which has the role of astringent, antibacterial, can make the patient’s veins within the thrombus formation speed up, the patient will shrink and disappear after the injection of hemorrhoid elimination, so as to achieve the purpose of cure. According to the survey, the cure rate for stage I to III hemorrhoid patients can reach 75% to 89% with Hemorrhoid Injection. And polyglactin is a foam-type sclerosing agent whose mechanism of action is to destroy the lining of the venous vessels, causing sterile inflammation of the vessels and surrounding tissues, and through the absorption of sterile inflammation, fibrous strips are formed, thus achieving closure of the vascular lumen. Both softening and shrinking agents and sclerosing agents have their own advantages and scope of adaptation, and patients should choose them under the advice of their doctors. Second, although effective, injection methods have limitations and often require strict postoperative care and lifestyle adjustments in compliance with medical advice to further promote hemorrhoid healing. References [1] He Yunlong,Cheng Zhuoxin. Advances in the surgical treatment of hemorrhoids [J]. Electronic Journal of Clinical Medicine Literature,2017,4(49):9693+9696. [2]Liao JY, An AY, Feng DY, Feng YN, Wang CH, Bai ZY, Wang X, Li K. Comparison of clinical efficacy of Paeonibe injection and internal hemorrhoid ligation in the treatment of bleeding internal hemorrhoids in the elderly[J]. Colorectal and Anal Surgery,2020,26(01):83-87. [3]Guan Yi,Li Changfeng.A comparative study of RPH combined with sclerosing agent antihemorrhoid spirit and polyglactin in the treatment of hemorrhoids[J]. Systemic Medicine,2021,6(21):124-127.