The World Health Organization has positioned H. pylori as the number one cancer-causing factor. Nowadays, 40% of people in Xuzhou are found to be positive for H. pylori. H. pylori is difficult to eradicate, so what do you do with it? Generally speaking, there are no uncomfortable symptoms to let it go, there are symptoms such as stomach pain, bloating, etc., the examination confirmed that there is gastritis (atrophic, intestinal epithelial hyperplasia type), such people must eradicate H. pylori type. Patients often ask: what to do if H. pylori can’t be killed? I think the key is the proper method of sterilization, especially the first sterilization must be “hard”, must be the proper method. The first irregular treatment, if you can not kill H. pylori, it is possible to cause bacterial resistance, to later completely kill the bacteria caused by difficulties, two sterilization can not kill, the bacteria will have their own protection, so do not continuous sterilization. A good time to recommend a sterilization is when a person suffers from other infections that require the use of antibacterial drugs, and then come back to kill the bacterium Helicobacter pylori. For example, if you have bronchopneumonia after a cold and need to use antibiotics, then a combination of treatments to kill H. pylori will kill two birds with one stone. H. pylori is a spiral-shaped, slightly anaerobic bacteria that requires very demanding growth conditions. it was first successfully isolated from gastric mucosal biopsies of patients with chronic active gastritis in 1983 and is the only microbial species known to be able to survive in the human stomach. H. pylori disease includes gastritis, peptic ulcer, and lymphoproliferative gastric lymphoma caused by H. pylori infection. The poor prognosis for H. pylori disease is gastric cancer. H. pylori is parasitic in the gastric mucosal tissue and is responsible for 67% to 80% of gastric ulcers and 95% of duodenal ulcers. Common symptoms in patients with chronic gastritis and peptic ulcers are: fullness, discomfort or pain in the upper abdomen after eating, often accompanied by other adverse symptoms such as belching, bloating, acid reflux and loss of appetite. Some patients may also experience recurrent episodes of severe abdominal pain and small amounts of bleeding from the upper gastrointestinal tract. It is generally believed that the process of H. pylori infection is as follows: H. pylori reaches the gastric mucosa through the mouth and settles into the infection, which causes chronic superficial gastritis after weeks or months and develops into duodenal ulcer, gastric ulcer, lymphoproliferative gastric lymphoma, and chronic atrophic gastritis after several years or decades, and the latter is the most dangerous factor leading to gastric cancer. Experts believe that H. pylori infection increases the risk of gastric cancer by 2.7-12 times, and that at least 35% to 89% of gastric cancers would not occur without H. pylori infection. It is a consensus among scholars in various countries that H. pylori disease is acquired and transmitted. The mode of transmission is not very clear, and the most likely route is oral-oral and fecal-oral transmission, which can be proved by the following experiments: 1) detection of H. pylori DNA from patients’ saliva, dental plaque and feces using PCR; 2) isolation of H. pylori from dental plaque and feces; 3) isolation of the same H. pylori strain from the feces of several members of the same family. H. pylori infection is found in people of different races and regions of the world and can be considered the most widespread chronic bacterial infection in adults. The general trend is that the prevalence of H. pylori infection increases with age, about 80% in developing countries and 40% in developed countries, and is slightly higher in men than in women. The age of infection in China is about 20 years earlier than in developed countries, with infection rates ranging from 45.4% to 63.6% between the ages of 20 and 40, and up to 78.9% above the age of 70. In addition, the infection rate is higher in the northern regions of China than in the southern regions. H. pylori infection is curable. The general principle of treatment is mainly antibiotics, supplemented by acid suppressants and bismuth preparations. Commonly used antibiotics include amoxicillin, clarithromycin, levofloxacin, metronidazole, tinidazole, etc. Patients should insist on taking them according to the doctor’s instruction after going to the hospital for examination, and check the efficacy in time.