Patients with malignant isolated fibrous tumors are treated with prompt surgery, and radiotherapy is only needed if the results are poor. Isolated fibrous tumors, usually junctional tumors with a low malignant component, require pathologic diagnosis. They are uncommon, mesenchymal tumors with fibroblastic differentiation and intermediate biological behavior, and are seen in many anatomical sites. The tumor accounts for less than 2% of all soft tissue tumors. The main treatment is surgical extended resection. The first surgery is critical, and it is necessary to extend the resection to completely remove the tumor tissue, which usually requires removal of more than one centimeter of normal tissue around the tumor to achieve radical cure. However, the effect of surgery may vary depending on where the tumor grows. If the surgery cannot completely remove the tumor tissue, patients need to cooperate with radiotherapy after the surgery to control the growth, development and spread of the tumor and achieve the purpose of preventing tumor recurrence. It is suggested that patients should go to the hospital for relevant examinations first, and according to the examination results and their own conditions, they should follow the doctor’s instructions to give surgical treatment. Regular review should be conducted after surgery to prevent tumor recurrence.