About 75% of patients with ankylosing spondylitis have mental disorders, of which 43% are depressed, and domestic studies have shown that 35.5%-76.5% of patients with ankylosing spondylitis are depressed, and the younger the patient and the lower the level of education, the more pronounced the depression; similar conditions exist in patients with rheumatoid arthritis, and the detection rate of depressive symptoms is 20%-60%. (1) Chronic physical illness with depressed mood is common and requires pharmacological intervention, and improvement in mood facilitates the treatment of physical illness, so symptomatic antidepressant treatment is necessary; (2) Depression has clear neurobiochemical and neurophysiological changes, for primary depression, pharmacological treatment is the first choice, better if supplemented with psychotherapy; (3) Patients with anxiety and depression are common in plain clinical practice. (3) Patients with anxiety and depression are common in clinical practice, most often both coexist, and depression is the primary and anxiety is the secondary, treatment is based on treating depression, while anxiety can improve with depression.