Coronary angina pectoris is a common and frequent disease in clinic, this disease cannot be cured at present and is a lifelong treatment disease. In the treatment method of drug therapy, interventional therapy and surgery, of which drug therapy is particularly important. Reasonable and standardized use of medication can significantly reduce the frequency of coronary angina attacks, improve the quality of life of patients, and prolong life. In this article, the daily oral medication for patients with coronary angina and how to rationalize the use of medication is introduced. Western medicine treatment drugs are divided into two categories of drugs to improve symptoms and improve prognosis, but considering the overlap of the two categories of drugs, they are combined and introduced. Commonly used western medical treatment drugs are mainly the following six kinds: 1, aspirin: through the inhibition of cyclooxygenase and thromboxane (TXA2) synthesis to achieve the role of anti-platelet aggregation, all patients as long as there are no contraindications to the use of drugs should be applied. The optimal dose range for aspirin is 75 to 150 mg/d. The usual dose is 100 mg per dose, taken every morning. The main adverse reactions are gastrointestinal bleeding or hypersensitivity to aspirin. Patients who cannot tolerate aspirin can switch to clopidogrel as an alternative treatment. 2, β-blocker: can inhibit cardiac β-adrenergic receptors, thereby slowing the heart rate, weakening myocardial contractility, lowering blood pressure, in order to reduce myocardial oxygen consumption, can reduce angina attacks and increase exercise tolerance. The dose should be individualized, requiring the resting heart rate to be reduced to 55-60 beats/min after administration, and to 50 beats/min in patients with severe angina if there are no symptoms of bradycardia. β-blockers are contraindicated in patients with severe bradycardia and high degree of atrioventricular block, sinus node dysfunction, and with significant bronchospasm or bronchial asthma. Peripheral vascular disease and severe depression are relative contraindications to the application of beta-blockers. Common side effects are weakness, to the lower limbs, generally does not affect the treatment, after a period of time can often be relieved on their own. 3, nitrates: endothelium-dependent vasodilators, can reduce myocardial oxygen demand and improve myocardial perfusion, thus improving angina symptoms. Adverse effects of these drugs include headache, flushing, rapid heart rate and hypotension. 4, calcium antagonist: by improving coronary blood flow and reduce myocardial oxygen consumption to relieve angina pectoris, for variant angina pectoris or coronary artery spasm-based angina pectoris, calcium antagonist is the first line of drugs. Peripheral edema, constipation, palpitations, facial flushing is a common side effect of all calcium junction antagonists, hypotension also occurs from time to time, other adverse reactions also include headache, dizziness, weakness and weakness. 5, lipid-regulating drugs: coronary heart disease patients with low-density lipoprotein cholesterol (LDL-C) target value should be <2.6mmol / L, for very high-risk patients (diagnosis of coronary artery disease combined with diabetes mellitus or acute coronary syndromes), the therapeutic target for LDL-C <2.07mmol / L is also reasonable. Commonly used drugs are statins or fibrates, and biochemical indicators such as aminotransferases and creatine kinase should be monitored when applying the drugs, so that liver damage and myopathy that may be caused by the drugs can be detected in a timely manner. 6, angiotensin-converting enzyme inhibitors (ACEI): all patients with coronary artery disease can benefit from ACEI therapy, but low-risk patients may benefit less. The common adverse reaction is dry cough, such as dry cough can not be tolerated can be changed to angiotensin II receptor blockers.