The patient, female, 62 years old, had a history of “diabetes” for 15 years, had taken oral medication for a period of time (5-6 years) at the beginning, then changed to insulin treatment due to poor blood sugar control, recently used Novalis 30 24u in the morning, 10u in the middle and 12u at night, blood sugar fluctuates greatly, the highest is about 20mmol/l, recently felt significant weight loss, stool frequency increased, accompanied by panic. Recently, he felt that his body weight had dropped significantly, and the number of stools had increased, accompanied by panic. Biochemistry on admission: normal liver and kidney function, blood Na: 134.8 mmol/l, HBA1C: 11.8%, urine microalbumin: 2.9 mg/l, A function: TSH: 0.02 uim/ml, FT3: 14.07 pmol/l, FT4: 3.61 ng/dl; T3: 4.56 nmol/l, T4: 201.47 nmol/l. l,electrochemiluminescence check: TRAB:10.31 IU/L,TPOAB:157.0 IU/mL,TGAB<20.0 IU/mL,indirect immunofluorescence check: IAA negative ICA weakly positive GAD positive,OGTT islet function: time fasting half hour one hour 2 hours blood glucose mmol/l25.2034.3639.5043 .00 insulin pmol/l2.433.503.673.52 treatment plan: tabazol: 15mgpoqd, insulin: 10mgtid, vitamin B1:10mgpotid. recheck liver and kidney function is normal, blood picture is normal, patient's economy is average, can't accept insulin pump treatment, blood sugar control: Novalis: 12u-11u-11u; glycine Insulin: 13u at 8pm; blood glucose: 5-14mmol/l.