Diabetic lower limb vasculopathy needs to be treated with medications such as glibenclamide, insulin, aspirin, etc. In severe cases, lower limb vasculopathy needs to be treated by surgery. Diabetic lower limb vasculopathy firstly needs to control blood sugar, such as using glibenclamide, reglaneride, rosiglitazone, insulin injection to lower blood sugar and treat the primary disease. Normally, the total energy intake should be reasonably controlled, nutrients should be distributed, less food, more meals, more exercise and so on. The occurrence of lower limb vasculopathy, need to consider taking aspirin, thrombolysis and other treatments, serious cases need surgical treatment. When diabetes is complicated by vasculopathy of the lower limbs, the condition is usually more serious, and complications such as neurological symptoms and renal failure may also occur in the long term. It is recommended to seek timely medical treatment and use medication under the guidance of a doctor.