Considering cholangiocarcinoma actually has not been diagnosed at present, just more inclined to cholangiocarcinoma, which is the common descriptive term for abdominal CT or abdominal ultrasound, and pathologic examination is needed for confirming the diagnosis. Early stage of cholangiocarcinoma has no obvious clinical manifestations, while late stage patients may have right upper abdominal pain, abdominal distension, fatigue, lack of appetite, pottery white stools, jaundice, fever and other manifestations. Patients with cholangiocarcinoma need to undergo relevant laboratory tests, such as tumor marker test, CA199, AFP and other markers are elevated, abdominal CT, ultrasound, MRI and other tests can find bile ducts occupying, and combined with the clinical manifestations of the patients, cholangiocarcinoma can be diagnosed preliminarily. However, pathologic examination is needed to confirm the diagnosis. Cholangiocarcinoma is a malignant tumor with high degree of malignancy. Early detection of cholangiocarcinoma, surgical resection of tumor and postoperative radiotherapy can prolong the survival period and improve the quality of life of patients. Patients with bile duct cancer should go to the hospital for timely checkup if they have any discomfort, and should not be careless so as not to delay the treatment.