Hand-foot syndrome is a common skin side effect caused by chemotherapy drugs. It occurs on average at 79 days of drug administration (range 11-360 days) and is graded 1-3 according to severity (National Cancer Institute (NCI) grading scale). Grade 1 hand-foot syndrome: numbness, dullness of sensation, abnormal sensation, pins and needles, painless swelling or erythema or discomfort in the hands or feet, but does not interfere with normal activities. Grade 2 hand-foot syndrome: erythema and swelling with pain or/and discomfort in the hands or/and feet that interferes with daily life. Grade 3 hand-foot syndrome: Skin loss, ulcers, blisters, or severe pain and/or discomfort in the hands and/or feet that prevents the patient from working or performing daily activities. Many chemotherapy drugs, targeted drugs may cause hand-foot syndrome. Some chemotherapy drugs that may cause hand-foot syndrome include capecitabine, liposomal adriamycin, cytarabine, doxorubicin, vincristine, continuous infusion of adriamycin, and gemcitabine. Targeted drugs that are likely to cause hand-foot syndrome include: sonytinib (Sotan), sorafenib (Doximet), imatinib (Gleevec), and erlotinib (Troche). Therefore, take care to prevent and control hand-foot syndrome when using these drugs. How to prevent the occurrence of hand-foot syndrome (1) Avoid wearing tight shoes (2) Avoid repeated rubbing of hands and feet (3) Apply appropriate amount of local lubricant such as balm, lubricating lotion, or other lanolin containing lotion frequently In case of hand-foot syndrome, consult your doctor promptly and take appropriate treatment measures according to the severity.