Todd’s palsy was first described by the London physiologist Robert BentleyTodd in 1849 and named after him.Todd’s palsy is an abnormality of the nervous system that occurs in people with epilepsy, that is, a brief paralysis that occurs at the onset of epilepsy. The paralysis can be localized or generalized, but usually occurs on only one side of the body. It most commonly follows a generalized tonic-clonic seizure (grand mal) and may last for several hours or occasionally for several days after the seizure has passed. The etiology of the condition is unclear, but there are two hypotheses. One is the attrition theory, in which depletion of the motor cortex leads to prolonged hyperpolarization of neurons. The second is a transient motor fiber inactivation due to NMDA receptor activation. Since the paralysis disappears quickly, the treatment of the disease is symptomatic and supportive. The prognosis of the disease is related to the degree of epilepsy. The most significant aspect of the disease is the differential diagnosis with stroke. In the acute phase, certain strokes can trigger a limited seizure. And if Todd’s paralysis occurs in such a context, the patient’s neurological condition is often overestimated, thus leading to medical interventions such as thrombolytic therapy errors. For such reasons, thrombolytic therapy is generally considered a relative contraindication for seizures that occur in the acute phase of stroke, especially if evidence of cerebrovascular infarction is still lacking before vascular imaging. Thrombolytic therapy is contraindicated in cases where the diagnosis is not clear. Antiepileptic, anticoagulation, vasodilatation, brain cell nutrition, free radical scavenging, and acupuncture are recommended first, while further investigations, such as diffusion-weighted imaging in CT and MRI, are important for the diagnosis of cerebral ischemic stroke as soon as possible. Prevention of paralysis relies on prevention of the underlying cause. Risk control for stroke can reduce blood pressure and high cholesterol levels. Seat belts, airbags, and helmets reduce the risk of motor vehicle accidents and injuries. Good prenatal care can help with prevention.