How soon the first lumbar compression fracture does not hurt depends on the severity of the patient’s condition and treatment, and should be analyzed on a case-by-case basis, not as a generalization. In the case of compression fractures in young patients less than 60 years old, without neurological symptoms and with compression not exceeding 1/4 of the vertebral body height, no treatment is necessary and observation is sufficient. Generally, the pain can disappear after 2 months of absolute bed rest, but the exact time varies from person to person. If the height of the compressed vertebral body exceeds 1/4 or if the compression fracture does not combine with nerve injury in patients older than 60 years old, due to their age and obvious osteoporosis, vertebroplasty surgery is generally recommended, which can be painless on the first day after surgery at the earliest and can be basically recovered in about 3 months after surgery. In addition, patients with compression fractures of the first lumbar spine are recommended to perform daily limb massage and functional exercises, avoid prematurely getting out of bed, and pay attention to dietary regulation, which can appropriately increase the intake of calcium-containing substances.