Serious mental illnesses are schizophrenia, major depressive disorder, bipolar disorder, anxiety disorder, mania, obsessive-compulsive disorder, mental disorders due to epilepsy, etc. They are a group of recurrent and incurable diseases and seriously affect family and social life. Because of the complexity and variability of these disorders and their persistence, they also receive close attention from families and society as a whole, and everyone is looking for new ways to cure these disorders! Usually, severe mental illnesses are treated in hospital, and doctors use long-term systematic medication, psychological counseling, social education and supplementary support therapies, and most patients’ psychiatric symptoms will be relieved and improved. However, regardless of the treatment, there are always a small number of patients whose psychiatric symptoms are difficult to control effectively, and psychiatrists and family members are at their wits’ end. Is there no ultimate solution to treat serious mental illness? In fact, there is no ultimate solution to treat any disease, but in comparing various treatment methods, the one that is relatively effective is considered the “ultimate solution”. For severe mental illnesses, experts recommend stereotactic surgery for minimally invasive treatment. The pathogenesis of severe mental illness is based on the abnormal expression of neurotransmitters in the nucleus accumbens of the brain. The purpose of stereotactic minimally invasive surgery is to control or eliminate psychiatric symptoms and achieve a cure by regulating the function of abnormal nuclei in the brain. 100 years of clinical practice has confirmed that regulating the nuclei of psychiatric patients such as the anterior limb of the internal capsule, cingulate gyrus and amygdala will effectively control or eliminate persistent psychiatric symptoms and make severe mental illness become mild or even completely cured. In the full treatment of severe mental illness, medication, psychology, rehabilitation, and surgery are all important parts of its full treatment. As to which treatment a patient should actually take, it is decided according to the severity of his or her condition. Only patients with severe mental illness may be considered for stereotactic minimally invasive surgery treatment. After all, the surgery is invasive, which requires the patient’s family, surgeon, and psychiatrist, to conduct a thorough examination, detailed evaluation and analysis of the patient before finally making an appropriate and reasonable choice. In conclusion, for severe mental illnesses, try the last resort – stereotactic minimally invasive surgical treatment – when other treatments are ineffective.