How to treat Parkinson’s disease? In the early stage, the main treatment is medication, such as levodopa drugs, which are often more effective, but usually after 3-5 years, the efficacy of the drugs decreases, the time of drug control becomes shorter and shorter, and some even completely ineffective, and many patients also have drug-induced side effects such as involuntary writhing of the whole body and the so-called on and off phenomenon. At this time, surgical treatment should be considered. The brain pacemaker (DBS) is the fastest progressing method for treating neurological diseases in recent years. It has completely replaced disruption (cytoknife) as an effective alternative therapy for Parkinson’s disease in Europe and America. How is the brain pacemaker a mysterious weapon? We may have heard of pacemakers, but brain pacemakers are still little known. In medical terminology, the brain pacemaker is called “deep brain stimulation therapy”, abbreviated as “DBS”, and was introduced to China in 1999. More than 30,000 cases of Parkinson’s disease have been treated with pacemakers worldwide, which is considered to be the second milestone since the invention of medication for Parkinson’s disease in 1968. It is different from the previous treatment of disruption. Destructive surgery is an operation that is destructive to brain tissue and has irrational and high complications, especially double sympathetic destructive surgery, which has more than 30% complications, and the number of people doing this operation in Japan and abroad is decreasing rapidly every year. Pacemakers, on the other hand, stimulate the inner nucleus of the brain with high-frequency electrical pulses from a stimulator to inhibit the discharge of abnormal nuclei, so that they can “change their ways” and eliminate the symptoms of Parkinson’s disease and achieve therapeutic effects. Symptoms that are difficult to control with disfiguring surgery, such as difficulty walking and turning over, can be improved with deep brain electrical stimulation therapy. This method is safer, with minimal risk of surgery and no permanent side effects. Since the brain stimulator can be adjusted by computer remote control outside the body to adjust the stimulation program and stimulation parameters, it can maintain good results in the long term. Recent research results also show that deep brain electrical stimulation also has a nerve cell repair effect, which can effectively control and slow down the progression of the disease. Since deep brain electrical stimulation does not damage brain tissue, it can still receive new treatments in the future, such as brain cell transplantation, gene therapy, and stem cell therapy.