The high cervical medulla is an important nerve center in the human body, where numerous nerve fibers from the brain converge densely, with a diameter equivalent to the thickness of an adult’s thumb, and the site is deep enough to cause serious consequences such as tetraplegia, urinary and fecal incontinence, and respiratory muscle paralysis. It is a very high-risk surgical site in the field of neurosurgery, neurosurgeons are often “discouraged”. Li Ma, who lives in Yinzhou, has been suffering from neck and shoulder pain for many years and has been treated as cervical spondylosis. In the past 2 months, the pain made it difficult for her to sleep, and at the same time there was numbness and weakness in the upper limbs. The tumor was rich in blood supply and had extensive adhesions with dura, spinal nerve and blood vessels, which made the surgery difficult and risky. After repeated discussions among the neurosurgeons, the patient not only faced pain but also the risk of paralysis if the condition was delayed any longer, so they decided to take on the heavy burden and perform minimally invasive surgery to remove the cervical medullary tumor for her. The operation was performed by Dr. Zhang Jianping, the chief surgeon, with the close assistance of Dr. Xu Yongkang and Dr. Jin Jianxiang, using the most advanced non-distraction technique and microsurgery technology in China. After more than 4 hours of intense surgery, the tumor was finally removed successfully, with less than 100 ml of intraoperative bleeding. At present, Ms. Li is recovering well and has been discharged from the hospital. The successful implementation of this surgery marks another new step in the field of high-risk and difficult neurosurgery in our hospital.