Tuberculosis skin test, also known as tuberculin test and PPD test, is used to diagnose tuberculosis, and the mechanism of action is to stimulate the body to produce a cellular immune response. The mechanism of action of the New Crown vaccination is humoral immunity, so there is no conflict between the TB skin test and the New Crown vaccination. There is no evidence of an effect between the two. Although there is no conflict between the TB skin test and New Crown vaccination, TB patients should be vaccinated with caution. If a patient is assessed by a physician to be in a stable phase of the disease, it usually does not affect New Crown vaccination, but if the patient is in the active phase of TB and has symptoms such as coughing, hemoptysis, and night sweats, New Crown vaccination is not recommended to avoid worsening discomfort. A TB skin test is usually recommended first. The results of the TB skin test are usually available after 72 hours, and if the results are normal and there are no contraindications to the New Crown vaccination, the New Crown vaccination can be administered. A strong positive skin test result is usually indicative of Mycobacterium tuberculosis infection and requires exclusion of active tuberculosis before vaccination with the New Crown vaccine, although medical advice should be followed. There are also clinical groups that should not receive the vaccine, including pregnant and lactating women, or patients with fever, allergies, or other serious illnesses, so precautions should be made before vaccination. It is necessary to observe for 30 minutes after the vaccination, to avoid water and overexertion in the near future, and to choose a light and easily digestible diet. Some patients may have febrile reactions, which are mostly common after vaccination, and at this time, they can drink more water to lower their body temperature.