The pterygopalatine ganglion is composed of the pterygopalatine nerve, the parasympathetic root from the facial nerve, the superficial rocky nerve, and the deep rocky nerve from the sympathetic plexus of the internal carotid artery, in the pterygopalatine fossa, with a diameter of about 3-4mm, the pterygopalatine ganglion can regulate the blood vessels of the head and face to alleviate the headache after it has been blocked or disrupted. Pterygopalatine fossa injection of hormones and local anesthetic drugs can quickly reduce the sensitivity of the nerve, reduce vascular excitability, patients in the pterygopalatine fossa puncture successful injection of drugs, headache more immediately reduce the discomfort in the eyes disappeared, the eyes become bright sense of vision, most patients will appear in the nose, the upper lip and the upper teeth of the numbness, which is the result of the blockade of the maxillary nerve, two hours after the sensation can be completely returned to normal, long-lasting hormones on the sensitive nerves, can provide long-term relief of headache. Long-acting hormone on sensitive nerves can relieve headache for a long time. The follow-up of the patients after the treatment shows good therapeutic effect, which can significantly reduce the degree of migraine and the frequency of attacks.