Li, a female, 28 years old, came to our department a year ago because of amenorrhea and obesity. Li had a job that everyone envied, but since she was 20 years old, she no longer had menstrual periods. Not only that, her appearance also changed significantly compared to before, her body shape became fatter and fatter, acne appeared on her face, and she even developed a beard, and she has not fallen in love or gotten married. For this reason, both she and her mother were very anxious and distressed. After a series of tests, we found that Li has a disease called “polycystic ovary syndrome”. After treatment, Li is now able to have normal menstrual periods every month, and her body shape is significantly thinner than a year ago, and the acne on her face is gone, as is her beard. Li said she now has hope for life. Polycystic ovary syndrome is a very common female endocrine disorder. Many women of childbearing age visit hospitals for long-term infertility after marriage, only to find out that it is polycystic ovary syndrome. Nowadays, this disease has a trend of low age, and it is even found in some middle school and high school students, so early detection and early treatment becomes especially important. Women should pay attention to the following changes in their body: 1. abnormal menstruation: irregular menstruation, amenorrhea. 2. 2, hairy: these patients because of the body androgen elevation, so there can be some female masculine appearance characteristics, such as the upper lip, jaw, chest, back, mid-calf, upper thighs on both sides and the perianal hair thickening, increase. It can also be accompanied by acne, excessive sebum secretion on the face, low and coarse voice, enlarged clitoris, throat knots and other masculine signs. 3, infertility: due to long-term non-ovulation, patients are mostly combined with infertility, sometimes there may be occasional ovulation or miscarriage. 4, obesity: obesity is mostly concentrated in the upper body, mostly since puberty, and gradually aggravated with age. 5. Acanthosis nigricans: gray-brown pigmentation in the skin folds of the labia, back of the neck, armpits, under the breasts and groin, etc., symmetrical, with thickened skin and soft texture. Polycystic ovary syndrome not only can affect women’s normal life, but also cannot produce progesterone due to the absence of ovulation. If long-term excess estrogen stimulates the endometrium, excessive endometrial hyperplasia can occur, and in serious cases, endometrial cancer can occur. Therefore, once a young woman finds the above changes in her body, she should go to the hospital in time to seek medical attention, lose weight and at the same time cooperate with medication to contain the disease in the bud, so that her future life will not be affected by the disease.