This clinical manifestation requires consideration of respiratory pathologies, most commonly lung infections, caused by viruses, bacteria, mycoplasma, chlamydia, rickettsia, fungi, and other pathogens, with varying degrees of congestion, edema, and exudation of inflammatory secretions from the lung tissue. In addition, non-infectious factors such as bronchiectasis, bronchial asthma, and diffuse interstitial fibrosis can also cause pain in the middle of the chest due to damage to the lung tissue and coughing. Rarely, bronchopulmonary carcinoma and alveolar cell carcinoma can also cause pain in the middle of the chest due to coughing as a result of cancer encroaching on the lung tissue.