Prednisone belongs to the glucocorticoid class of drugs. At night is the low tide of the body’s own glucocorticoid secretion, and when the glucocorticoid concentration is the lowest, the hypothalamus will secrete hormones that promote glucocorticoid release to regulate it. If prednisone is taken at night, it will easily increase the level of glucocorticoids in the body, thus blocking the body’s own glucocorticoid regulation, so prednisone should not be taken at night. When prednisone is used to treat connective tissue diseases such as dry tissue syndrome, systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, or nephrotic syndrome, it can be taken orally in the early morning at 7-8 am. Since the peak of the body’s own glucocorticoid secretion is in the early morning, taking prednisone at 7-8 a.m. can make the exogenous glucocorticoids provided in the drug, and the body’s own endogenous glucocorticoid rhythm get overlapped, so as to maximize the drug effect and enhance the effect of promoting inflammation absorption. And since the metabolism time of prednisone is similar to that of endogenous glucocorticoids, it does not significantly inhibit the release of hypothalamic-pituitary hormones. Generally speaking, glucocorticoids produce some irritation to the gastric mucosa, which may induce stomach pain, stomach acidity or increase the risk of gastric mucosal bleeding, and usually doctors will recommend taking them after meals. However, whether the prednisone is applied, stopped or reduced, it should follow the doctor’s instructions and should not be changed at will. If the symptoms of the disease worsen while taking it, or if there are obvious adverse reactions to the drug, you should promptly give feedback to your treating physician and change or reduce the dosage under the guidance of your doctor.