To observe the efficacy and side effects of trazodone and analgesics on chronic functional pain. The authors randomly divided 140 patients into 2 groups double-blind control, respectively, trazodone and depurative treatment for 4 weeks, using Hamilton depression scale and clinical efficacy assessment criteria for evaluation, and side effects were assessed by side effects scale. The results showed that trazodone was significantly more effective than depressants, with efficacy rates of 92,85% and 62,85%, respectively. The side effects were not serious. It was concluded that trazodone was effective in chronic functional pain with mild side effects. DISCUSSION: Chronic functional pain is more common in outpatient and general outpatient clinics. Huang Mingsheng et al. reported that it accounted for 30-60% of the patients, and Lu Guangzeng reported that it accounted for 13% of the total number of outpatient clinics. This type of pain is often associated with depression or is a somatization of depressive disorders. Some scholars believe that chronic pain is insidious depression. The efficacy and side effects of trazodone and analgesics on chronic functional pain are often observed. A total of 140 patients were randomly divided into 2 double-blind control groups, and were treated with trazodone and analgesics for 4 weeks, which were evaluated using the Hamilton Depression Scale and Clinical Efficacy Rating Criteria. The use of the Side Effects Analgesic Scale rating can delay treatment due to the lack of physician awareness of the disease. Trazodone is a heterocyclic new antidepressant, its mechanism of action is mainly selective inhibition of 5-HT and NE reabsorption, no anticholinergic effect, depression, anxiety, insomnia has a significant effect. Clinical studies have found that most patients with chronic pain have depressive disorders and their pain is improved by antidepressant treatment. In the author’s current study, 116 (83%) of the 140 patients with chronic pain who were eligible for depressive disorders and 65 (93%) of the 70 (including 12 with non-depressive disorders) who were treated with trazodone experienced pain relief. Tricyclic antidepressants previously reported to be used in the treatment of chronic pain are thought to be related to 5-HT, and maprotiline and venlafaxine appear to have analgesic effects by inhibiting NE reuptake. And clinical pharmacologic studies confirm that 5-HT and NE do produce analgesic mechanisms. Trazodone has dual effects of 5-HT and NE reuptake inhibition, and double-blind controlled treatment found that treatment of chronic functional pain with trazodone was more effective than simple analgesics, with efficacy rates of 92.85% and 62.85%, respectively. The efficacy was similar to that reported by Deng Hejang. The side effects of trazodone group were higher than those of ibuprofen group, mainly drowsiness, nausea, loss of appetite, and fatigue. However, they had little effect on the patients’ life and did not need to be treated, and the treatment compliance was better. Therefore, for patients with chronic functional pain, the diagnosis should be clarified as far as possible, and after exclusion of organic diseases, the application of trazodone antidepressant treatment can be considered, which often achieves better results in relieving intractable pain.