Patients with gastroenteritis who have high fever can be treated with oral acetaminophen and ibuprofen suspension to reduce fever. Acute gastroenteritis is one of the most common diseases in clinical practice. The main symptoms are nausea, vomiting, and in severe cases, vomiting of coffee-colored liquid, pain around the umbilicus, accompanied by diarrhea and solution of dilute watery stools. The main cause of acute gastroenteritis is partly related to unclean diet and cold. When the symptoms are mild, you can take oral medications that inhibit gastric acid secretion, such as omeprazole, combined with antiemetic drugs, such as domperidone and metoclopramide. If there is mild diarrhea, oral montelukast can be used to astringent the intestinal tract. If there is a combination of electrolyte disorders, fever and chills will appear when inflammation is more obvious, anti-inflammatory treatment can be taken, and levofloxacin can be used for anti-inflammatory treatment. If the body temperature is too high, oral antipyretic drugs such as acetaminophen and ibuprofen suspension are needed.