Most children with epilepsy can have their seizures controlled through reasonable medication. The primary factor in seizure control is long-term regular medication, and only by maintaining a stable effective blood concentration during the treatment process can seizures be effectively controlled. The nurse should first provide parents with guidance on medication, especially parents of children diagnosed for the first time, to make them fully aware of the importance of taking the correct medication, and insist on supervising and assisting the child to take the medication regularly and quantitatively as prescribed by the doctor. During the treatment process, strictly follow the doctor’s instructions to increase or decrease the dosage or change the medication. Regularly recheck liver and kidney functions and blood concentration. Some parents think that antiepileptic drugs have many side effects and can affect liver and kidney function, and even think that antiepileptic drugs are sedatives and children will become more and more stupid. For such parents, they should be instructed to correctly understand the toxic and side effects of drugs, correctly weigh the consequences of seizures and the toxic side effects of drugs, and introduce more examples of successful treatment to parents so that they can relieve their worries and thus improve the compliance of treatment.