Diabetic peripheral neuropathy is a common neurological complication of diabetes mellitus. The pathogenesis of diabetic neuropathy is mainly related to metabolic disorders caused by hyperglycemia, vascular injury, neurotrophic disorders, oxidative stress, chronic low-grade inflammation and genetic factors. More than half of the patients may have symptoms, the most common being burning pain, electric shock-like or pins and needles sensation, sensory numbness and sensory hypersensitivity. Typical neuropathic pain is often worse at night, and symptoms are most often found in the feet and lower extremities, and in some patients may also involve the hands in a glove-sock-like distribution. There are many causes of peripheral neuropathy, should be differential diagnosis of drug metabolism and other causes of peripheral neuropathy, such as the appearance of both sides of the limbs of sensory impairment, numbness, weakness, should be timely to the hospital.