The choice of appropriate antiepileptic drugs is the key to the treatment of epilepsy, and some of the types of antiepileptic drugs commonly used in clinical practice are introduced. 1, barbiturates: phenobarbital, deoxynivalenol, methobarbital, etc., mainly through the central inhibitory neurotransmitter r-aminobutyric acid receptors, increase the inhibitory chloride ion inward flow and play an anticonvulsant effect, but also a sodium channel blocker. It is also used in tonic-clonic seizures, partial seizures, neonatal epilepsy and persistent epilepsy. 2.Ethylparaben: phenytoin sodium, methotrexate, etoposide, etc.. Among them, phenytoin sodium is the representative, the main mechanism of action is sodium channel blocker, blocking the repeated firing of neurons and reducing the post-tonic potential. It is indicated for tonic-clonic seizures and partial seizures, but can aggravate atonic seizures. Intravenous dosage forms are used for persistent status epilepticus. However, the use of phenytoin sodium has gradually decreased in recent years due to the narrow antiepileptic spectrum, similar therapeutic and toxic amounts, large effects on cognition, obvious drug see interactions, and teratogenic effects on the fetus. 3, double-chain fatty acid class: sodium valproate, magnesium valproate, epileptic an, etc. Valproic acid has multiple antiepileptic mechanism of action, effective for primary generalized seizures of various types, such as tonic-clonic, disorientation, dystonia, myoclonus; effective for partial seizures, and can be used to prevent hyperthermic convulsions. The intravenous form can be used for the rescue of persistent status epilepticus. The advantages of sodium valproate are a broad antiepileptic spectrum, effective in all types of epilepsy, few allergic reactions, low cognitive effects, and no hepatic enzyme-inducing effects. The disadvantage is that female patients may experience menstrual disorders and polycystic ovaries after use, and the teratogenic effect is obvious. 4. Succinimides: ethosuximide, methylsuximide, etc. It is mainly used for aphasic seizures and is less effective for other types of epilepsy. 5, benzodiazepines: diazepam, nitrazepam, clonazepam, clorazepam, etc. Clonazepam is mainly used for the adjuvant treatment of infantile spasms, myoclonic seizures, atonic seizures, and atypical aphasic seizures. 6. Iminoglycosides: carbamazepine, oxcarbazepine. The main mechanism of action is to block sodium channels, inhibit neuronal firing and stabilize cell membranes, thus exerting antiepileptic effects. Indications: For partial seizures, including simple partial and complex partial seizures; partial seizures secondary to tonic-clonic seizures. May aggravate myoclonic seizures and atypical disorientation. Common adverse reactions include rash (5%-15%), leukopenia, and hyponatremia. Teratogenicity is small relative to sodium phenytoin and sodium valproate. 7, sulfonamides: acetazolamide, zonisamide, etc. 8, new antiepileptic drugs: oxcarbazepine, lamotrigine, topiramate, levetiracetam. 9, special types: adrenocorticotropic hormone (ACTH), adrenal glucocorticoids, immunoglobulins, etc.