Vaginitis is a series of inflammatory diseases of the reproductive system caused by bacteria, gonococcus, syphilis spirochetes, mycoplasma, chlamydia or due to the decline of ovarian function and lowered estrogen levels. If the vaginitis is not caused by ovarian function, it can be cured with medication under the guidance of a doctor, but some of them do not improve significantly even after a long period of local or even systemic medication, resulting in a prolonged treatment, even if the course of treatment is cured, and relapses after a short period of time. 1, treatment medication is not regular, the course of treatment is not enough, the dose is not enough, failure to regularly review, not sure that the disease is healed before stopping medication, can not completely kill the pathogens, residual pathogens in the local can continue to reproduce, so that the symptoms can not be relieved resulting in recurrent attacks, can not be cured. 2. Inflammation is caused by mixed infections, and drugs for one pathogen alone cannot kill the pathogens of mixed infections, which may lead to serious dysbiosis of the vaginal flora and the production of drug-resistant strains of bacteria, making treatment difficult. 3. Some vaginitis can be contracted through sexual intercourse, direct or indirect contact. For example, trichomoniasis and mycobacterial vaginitis, if the male partner is infected, it can be transmitted to the female partner through sexual intercourse, so the spouse or sexual partner should be treated simultaneously. 4. Patients who are treated with broad-spectrum antibiotics or hormones for a long time are prone to decreased body resistance and dysbiosis, which can make vaginitis difficult to cure. During the treatment period, you should keep your vagina clean, wash your vulva regularly, change your underwear regularly and avoid sexual intercourse. Underwear and towels should be disinfected by boiling and exposed to sunlight. 6. The presence of other diseases. You should be alert to the possibility of diabetes mellitus for fungal vaginitis that is not cured for a long time, because high blood sugar increases the level of sugar in the vagina, and after the action of lactic acid bacteria, the vagina is acidic and suitable for fungal reproduction and growth. If diabetes mellitus is not controlled, fungal vaginitis will be difficult to control. Therefore, it is important to consider various aspects of vaginitis that has not been cured for a long time and remove all the unfavorable factors to achieve the best treatment effect.