A 75-year-old male was admitted to the hospital with “shortness of breath after activity, chest tightness for 2.5 years, epigastric pain and fever for 20 days”. The patient had chest tightness and shortness of breath after activity 2 years ago, without special treatment, and intermittent epigastric pain with fever up to 40℃, accompanied by mild yellowing of the skin, 20 days ago. He was diagnosed as “coronary heart disease, left main stem lesion; biliary tract stone and obstruction, biliary tract infection” in Northwest ×× Medical University Hospital. The anti-infection treatment was ineffective, and the high fever did not subside. Due to the patient’s age, serious condition and high risk of surgery, he was transferred to Beijing ×× Cardiovascular Disease Hospital. Due to the need for multidisciplinary joint treatment of gastroenterology with cardiac surgery and anesthesiology, and the patient’s persistent high fever and extreme weakness, the surgical risk was extremely high, and further treatment was not possible. Later, he was referred to the Heart Center of the First Affiliated Hospital of Tsinghua University on the recommendation of his physician. Professor Wu Qingyu personally organized relevant experts to carefully analyze the condition and determine the treatment plan. First, the anesthesiology department and the gastroenterology department jointly performed “retrograde cholangiopancreatography + papillary sphincter dissection and stone removal via endoscopy” (ERCP + ESD) under anesthesia, but due to the left main stem of coronary artery disease is very prone to sudden death, the therapeutic risk is very high. With the close cooperation between the Department of Anesthesiology and the Department of Gastroenterology, the biliary obstruction was successfully relieved. The patient’s fever and jaundice gradually decreased, and antimicrobial drugs were selected according to the drug sensitivity test of Enterococcus faecalis in the blood bacterial culture. One week later, the patient’s body temperature was normalized, his mental state improved, and his appetite significantly improved. After controlling the infection, Dr. Zhang Mingkui, the chief surgeon, performed coronary artery bypass grafting (4 bridging vessels) and the operation went smoothly. On the first day after the operation, the patient developed atrial fibrillation with fast-slow syndrome, and the clinical medication was greatly restricted. The patient was urgently treated with a temporary pacemaker by Dr. Tao Zhang, an electrophysiology expert of the Cardiac Center, and the patient changed to sinus rhythm after treatment. After multidisciplinary joint treatment by anesthesiology, gastroenterology, endoscopy room, catheterization room, cardiac surgery, operating room, cardiac surgery recovery room, electrophysiology group of cardiology, the patient recovered well and was discharged from the hospital successfully.