Chronic fatigue syndrome is a syndrome highlighted by prolonged extreme fatigue, mostly occurring in people aged 20 to 50 years old, and more common in women. It can often be accompanied by symptoms such as low fever, headache, generalized muscle and joint pain, and insomnia. So far the exact cause of the disease is unknown, some people believe that it is related to viral infection, but it is generally associated with long-term overwork, high mental stress, diet and nutrition structure is not reasonable, irregular life and caused by neurological, endocrine and immune dysfunction. Typical cases show chronic fatigue, which is aggravated after activity. The cause of chronic fatigue syndrome is not known, and there is no special treatment method in Western medicine. According to Chinese medicine, the spleen is the master of muscles, the liver is the master of tendons, and the kidney is the master of bones, and the three are closely related to physical fatigue and mental exhaustion. Abnormalities in the functions of the liver, spleen and kidney can lead to the occurrence of chronic fatigue syndrome, with long-term extreme fatigue and weakness, mental exhaustion, reduced work efficiency, and mental and emotional symptoms such as pain, depression or irritability. Treatment should grasp the disease mechanism of liver, spleen and kidney imbalance, and focus on strengthening the spleen and tonifying the kidney. 1, to physical fatigue, physical strength decline, should be mainly to strengthen the spleen, liver, and kidney, can be used ginseng, astragalus, atractylodes, licorice, Chai Hu, etc.. Such as astragalus chicken (astragalus, Chen Pi, cinnamon, etc. stewed chicken), tonic porridge (ginseng, astragalus, angelica, licorice, Chen Pi, Zizhu, Atractylodes, coix seeds, etc. boiled porridge) for dietary therapy. 2, mental fatigue, lower work efficiency, to soothe the liver and benefit the kidneys, and also to nourish the spleen, can be used Chai Hu Shu Liver Pills. 3. For those who are mainly depressed, use Angelica sinensis, Chai Hu, licorice, jujube, raw earth, rehmannia, etc. If you use Ganmai Dazao soup to boil porridge for dietary treatment, or take Zhuangyao Pill orally. 4.For those who are mainly irritable, they can use Chai Hu, Licorice, Paeonia lactiflora, Citrus aurantium, Radix Rehmanniae, Tortoise Plate, etc. 5.For those who are weak and have repeated external sensations, they can supplement with the method of benefiting qi and strengthening yuan by consuming duck with winter worms (duck stewed with Cordyceps sinensis) and chicken with eight treasures (chicken stewed with ginseng, Atractylodes sinensis, licorice, angelica, Chen Pi and Ganoderma lucidum). For those who also have sore throat and low fever, Chai Hu and Huang Qi can be given. For those with insomnia and dreaminess, nourish the heart and calm the mind, and give sour date seeds. In addition, the study also found that some traditional Chinese medical food supplies such as honey, pollen, gum, ants, etc., also have anti-fatigue effects, and these health foods can be used appropriately. Chronic fatigue syndrome is a disease name recommended by the Centers for Disease Control in the United States. It is a clinical syndrome in which a healthy person experiences severe generalized lethargy for unknown reasons, accompanied by mental symptoms such as low fever, headache, muscle pain, depression, poor concentration, and sometimes swollen lymph nodes that interfere with normal life. Previous lack of awareness of this disease has misdiagnosed many such patients as neurasthenia. For this reason, the Centers for Disease Control has developed a diagnostic criteria for this disease. (1) Main criteria: 2 of the following must be present: (1) Severe and debilitating fatigue of recent onset, lasting at least 6 months. (2) No medical or psychiatric disease causing fatigue, such as malignancy, autoimmune disease, infectious disease, neuromuscular disease, drug addiction, poisoning, etc., is found. (2) Secondary criteria: At least eight of the following symptoms are required: widespread headache, muscle pain, arthralgia, fever, sore throat, pain in the neck or axillary lymph nodes, muscle weakness, tiredness lasting more than 24 hours after light labor, psychoneurological symptoms (such as irritability, forgetfulness, inattention, difficulty in thinking, depression, etc.), sleep disturbance, sudden onset of fatigue, etc. (3) Objective criteria: at least 2 of the following symptoms and signs: hypothermia (oral temperature 37.6～38.0℃ or anal temperature 37.9～38.8℃); non-exudative pharyngitis, pain in the throat that lasts for a long time; mild enlargement of the lymph nodes in the neck or axilla with pressure pain. The etiology of chronic fatigue syndrome is not well understood. Initial studies by experts suggest that it is related to infection with the EBV virus. Since the disease often presents with low-grade fever, sore throat and enlarged lymph nodes, it is a different disease from neurasthenia.