If thrombotic thrombocytopenic purpura is not treated in time, the success rate of cure is very low, about 10-20%. The disease is also more likely to recur after cure. Currently, thrombotic thrombocytopenic purpura is treated with medication and surgery. Plasma exchange has reduced the mortality rate from 90% in the past to about 10% now. 1. Drug therapy: thrombotic thrombocytopenic purpura is an autoimmune disease, so it is usually treated with immunosuppressants and glucocorticoids. For example, dexamethasone and cyclophosphamide are used simultaneously to stabilize the endothelial cell membrane and platelet function and inhibit autoantibodies, but the dosage should be careful to avoid infection. 2. Surgery: Plasmapheresis is the first choice for thrombotic thrombocytopenic purpura, which can effectively remove autoantibodies and vWF multimers from the blood and reduce symptoms. For patients with more serious conditions, splenectomy can also be used to alleviate the condition. Thrombotic thrombocytopenic purpura is a diffuse vascular disease with a rapid onset and many complications, and generally has a poor prognosis. However, patients actively cooperate with the doctor’s treatment also has a certain chance of cure, the specific circumstances should be based on the patient’s disease progression comprehensive consideration to take different treatment methods.