Blood uric acid 650 μmol/L is usually more serious and requires active treatment. Uric acid is the end product of purine metabolism, when the production of urate is excessive and/or the excretion of uric acid by the kidneys is reduced, the concentration of uric acid in the blood will increase, forming hyperuricemia, long-term elevation of blood uric acid may cause gout, which is considered to be related to purine metabolism disorders. The diagnostic standard of hyperuricemia is that the fasting blood uric acid level is greater than 420 μmol/L on two occasions not on the same day, and the blood uric acid of 650 μmol/L is already significantly higher than the upper limit of hyperuricemia, which belongs to the elevated level of uric acid, and it may induce gout, renal function damage, cardiovascular disease and so on, therefore, the blood uric acid of 650 μmol/L is usually more serious. Patients with elevated blood uric acid need to actively adjust their dietary structure, limit or avoid purine-rich foods, and pay attention to drinking a lot of water, which can increase the excretion of uric acid. In addition, uric acid-lowering drugs can be used, such as benzbromarone, febuxostat and so on. It is recommended that patients with elevated blood uric acid should go to the rheumatology and immunology department of regular hospitals in a timely manner, and follow the doctor’s instructions for standardized treatment, and the medication should be used under the guidance of a professional doctor, and should not be used on its own.