How to properly understand and treat celiac disease

  Cervical erosion is a common and frequent disease in women. The literature reports that in married and fertile women, the prevalence is as high as 40% to 60%, and factors associated with its development include cervical trauma. Celiac disease can cause increased leucorrhea, bloody leucorrhea or post-coital bleeding, which affects life and work. Therefore, those with cervical erosion with symptoms should be actively treated. But for those who have cervical erosion without any symptoms, whether they need to deal with it, there are some new concepts in recent years, which are introduced as follows.  1, the misconceptions about cervical erosion (1) have sex to suffer from cervical erosion at present, the real cause of cervical erosion is still unclear, it is generally believed that mechanical stimulation or injury after marriage, such as childbirth, abortion or too frequent sex can cause varying degrees of cervical squamous epithelial destruction, cervical local resistance is reduced, easy to cause cervical inflammation. However, it is clinically found that women who are not sexually active still have cervical erosion, sometimes even severe erosion. Therefore, for unmarried, or non-sexual women, if there is persistent increased leucorrhea, or accompanied by changes in color and texture, they should visit a gynecological clinic to identify the cause and provide timely treatment.  (2) Long-term severe cervical erosion can become cancerous Many women with cervical erosion are worried about whether cervical cancer will occur. It is believed that the heavier and longer the cervical erosion is, the more likely cervical cancer will occur. Theoretically, cervical erosion is a pathological change that is caused by the replacement of the squamous epithelium of the cervix by the columnar epithelium, rather than true erosion. Cervical cancer, on the other hand, is an abnormal change in the squamous epithelium of the cervix, which is mainly caused by human papillomavirus (HPV) infection. The pathogenic factors and pathogenesis of the two are different, as are the pathological changes. Therefore, simple cervical erosion, if not combined with HPV infection, does not lead to the development of cervical cancer. However, women with cervical erosion should be reminded to perform cervical exfoliation cytology examination during gynecological examination to initially exclude the possibility of cervical cancer. It is difficult to distinguish early cervical cancer from cervical erosion by gynecological examination alone. If possible, HPV test should be performed along with cervical exfoliation cytology examination.  (3) Vaginal douche is needed for cervical erosion treatment. The surface of female vaginal mucosa is squamous epithelium, which is affected by female sex hormones and undergoes periodic shedding for protection. At the same time, the squamous epithelium secretes glycogen, which is broken down into lactic acid by the lactobacilli that live in the vagina, thus maintaining an acidic environment in the vagina and inhibiting the growth and reproduction of bacteria.  Celiac disease is not caused by bacterial infection. If you apply disinfectant, antiseptic, anti-itch and anti-inflammatory lotion to douche the vagina, it may destroy the protective barrier of the vagina itself, which is not only not beneficial to celiac disease, but also may cause secondary vaginal infection. Therefore, if celiac disease is not accompanied by vaginal inflammation, the application of local vaginal douches is not advocated.  (4) Celiac disease can be cured At present, the most widely used method to treat celiac disease in China is physiotherapy. It is usually believed that physiotherapy can cure cervical erosion at once. In fact, in the absence of a clear etiology, it is impossible to completely cure cervical erosion, regardless of the conservative treatment methods. Clinically, it is often encountered that after physiotherapy for cervical erosion, the erosion area becomes smooth (columnar epithelium is replaced by squamous epithelium), but after a period of time, cervical erosion may appear again. The reason for this is that whether you apply microwave, electric ironing, laser or freezing methods, the principle is to destroy the surface of the columnar epithelium of the erosion, so that it necrosis, crust off, new squamous epithelium grow into, to achieve “cure” J. If the real cause is not removed, cervical erosion may occur again.  The main basis is: (colposcopic observation of the erosion surface, for the intact columnar epithelium, because the columnar epithelium is a single layer, and the interstitial under it is not pathological changes. The interstitium underneath is red in color, so it looks red celiac-like to the naked eye. It is not a true celiac disease. This change is related to the displacement of the junction between the squamous and columnar epithelium of the cervix. Colposcopic observation of cervical “erosions” is a squamous-columnar junctional transformation zone.  Based on these new ideas, there are new perspectives on the treatment of cervical erosion. Only lymphocytic and plasma cell infiltrates in cervical biopsies are considered pathologically significant in chronic cervicitis. When there is no pathogenic microbial infection, cervical “erosion” may have no clinical symptoms or may only show increased discharge and does not require treatment. “It is often accompanied by inflammation, and after treatment for the cause and pathogen, the symptoms can mostly resolve or disappear on their own. Currently, there is a problem of over-treatment of cervical “erosions” without inflammation in clinical treatment. Therefore, the following recommendations are made.  (1) <30 years old, for simple, superficial erosion is mostly physiological changes, no special treatment is necessary.  (2) If you are >30 years old or have granular erosion, asymmetric erosion, contact bleeding, or different cervical hardness, you should undergo a three-step cervical screening to exclude cervical lesions.  (3) Granular or papillary erosions that are combined with inflammatory symptoms such as increased leucorrhea and vulvovaginal pruritus should be treated. In case of cervical cancer, local medication or physiotherapy is recommended.  (4) There are many physiotherapy methods, but the treatment principles are the same and the efficacy is similar. The key is to master the correct indications, standardize the operation and pay attention to the peri-therapeutic treatment.  (5) Before performing gynecological surgery, especially before treatment of cervical lesions, routine cervical cytology, HPV testing and colposcopy are emphasized.  At present, the concept, pathogenesis and management of cervical erosion are not yet unified, especially the new concepts proposed, which deserve consideration and in-depth study by clinical workers in obstetrics and gynecology as well as pathologists.