Urine specific gravity 1.005 belongs to the low, may be due to physiological factors or urological pathology caused by physiological factors do not need treatment, caused by urological diseases according to the type of disease generally available antidiuretic drugs, drugs to improve renal function, anti-infective drugs treatment. 1. Physiological factors: low urine specific gravity can also be seen in such factors as excessive water intake, mental polydipsia and diuretic treatment, at this time generally do not need drug treatment. Pay attention to personal hygiene and environmental hygiene clean, develop good living hygiene habits, always keep a relaxed and happy mood. 2. Antidiuretic drugs: If urinary avalanches occur, there may be polyuria, irritable thirst, decreased urine specific gravity or hypotonic urine and other manifestations, which can be treated with antidiuretic drugs, such as chlorsulfopropylurea, carbamazepine and so on. 2. Drugs to improve renal function: if the renal tubules are damaged, the concentration ability is inhibited, the concentration of urine will also be inhibited, and the urine specific gravity will be reduced. We should actively treat the primary disease and improve the renal function, we can take oral urethane granules, renal failure tablets and other drugs to relieve renal insufficiency as prescribed by the doctor, and do hemodialysis regularly, and if necessary, perform renal transplantation surgery. 3. Anti-infective drugs: If the specific gravity of urine decreases and the number of white blood cells in urine increases, it is recommended to carry out further urine culture examination. If pathogenic bacteria can be found in the culture, it is recommended to take oral anti-infective drugs. Commonly used are levofloxacin hydrochloride capsules and so on. Urine specific gravity of 1.005, it is recommended to consult a doctor in time, further examination to clarify the condition, follow the doctor’s instructions and active treatment, do not self-medication.