Ozone, also known as superoxide or strong oxygen, molecular formula O3, English name Ozone, human beings have discovered ozone for more than two hundred years. Ozone is extremely strong oxidizing, its oxidizing capacity is twice as high as chlorine, and sterilization is 600-3000 times faster than chlorine. Research has proved that ozone can also quickly kill bacteria, fungi, viruses, etc., and will not produce drug resistance, is a broad-spectrum, efficient, rapid, economical disinfection and sterilization agent. At present, the international medical aspects of a variety of uses, our pain department in the ozone treatment has also achieved promising results, now combined with clinical practice on the role of ozone in the clinical aspects of a brief introduction. 1, in the diagnosis and treatment of pain Ozone can produce oxidation, anti-inflammatory, analgesic effect in the tissue, and can specifically destroy the intervertebral disc nucleus pulposus cells. Therefore, it is widely used in: cervical and lumbar intervertebral disc herniation; frozen shoulder, tennis elbow, tenosynovitis, myofasciitis, the third lumbar transverse syndrome and osteoarthritis pain and other chronic injuries of the locomotor system; ankylosing spondylitis, rheumatism, rheumatoid pain; postherpetic pain, trigeminal neuralgia, sciatica and other neuralgia, and even cancer pain in a variety of pain treatment. 2, in the surgical infection Because of its powerful sterilization, oxidation, can improve wound healing, stimulate immunity. For Escherichia coli, Staphylococcus aureus, Bacillus subtilis, airborne bacteria, hepatitis B virus, etc., the sterilization rate is 100%, and it plays a great role in intractable infected wounds, fistulas, decubitus ulcers, fungal infections, varicose veins, and colitis. 3, in the skin disease of Fusarium tandem, Fusarium fumigatus, the killing rate is greater than 99.5%. It can completely cure fungal infections such as athlete’s foot, ringworm, tinea corporis and viral infections such as common warts and condyloma acuminatum. 4, in the gynecological inflammation is mycosis vaginalis, vaginal odor, cervicitis nemesis, and does not change the acidic environment of the vagina, accelerate mucosal repair, enhance the local immunity. 5, in the oral cavity inflammation can be sterilized in the oral cavity anti-inflammatory, remove odor, promote oral mucosa repair, prevent the emergence of bacteremia in the process of tooth extraction, especially for pediatric caries ozone remineralization treatment. The above is some of the practice of our department in the clinical application of ozone, in the future, our “new weapon” but also for more patients to relieve pain. It is necessary to point out in particular that it is very necessary to choose precise ozone generating devices, determine the most suitable therapeutic concentration, and be operated by personnel with relevant technical knowledge, so as not to increase the damage of patients by blind operation.