Biologics are one of the biggest therapeutic advances in the field of rheumatology in the last decade or so, and are now widely used in the treatment of rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus. Previously, some patients with serious conditions and diseases with certain treatment difficulties such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus and other diseases can also be well controlled. There are many biologic agents for rheumatic immune diseases and many therapeutic targets, such as those targeting tumor necrosis factor, CD20, activated T cells, interleukin receptors, etc. More therapeutic targets are being discovered and used in therapeutic experiments. However, these therapeutic targets are also important sites for regulating the immune system of our body, so biologics should be applied under the guidance of doctors.