Atrial fibrillation is an important cause of stroke and thromboembolic events, and the incidence of stroke is 4-5 times higher in patients with atrial fibrillation than in those without atrial fibrillation. For patients with nonvalvular atrial fibrillation who cannot revert to sinus rhythm, left ear occlusion can be considered. I. Which patients with atrial fibrillation are the best candidates for radiofrequency ablation therapy? (Main indicators: not long duration, not old, not large atria) The first choice is typical paroxysmal atrial fibrillation, young (old, high surgical risk), no systemic heart disease, frequent episodes, no large atria, such patients are the most typical, the success rate of one RF ablation can reach 80%. For the second choice group, patients with atrial fibrillation lasting less than one year, with paroxysmal atrial fibrillation, atria not very large, and no underlying disease, the success rate is about 70%. Again, for patients with atrial fibrillation lasting for more than one year, with unknown medical history, with atria that have become large, and with some atrial fibrillation-related diseases, the effect of radiofrequency ablation is worse, with a success rate of 60% or even lower. Second, which patients with atrial fibrillation are the best candidates for left-ear occlusion therapy? Left-ear occlusion can eliminate patients’ dependence on long-term anticoagulation therapy and avoid intolerance, bleeding events and compliance problems caused by anticoagulants. All of the following conditions must be met 1. age >18 years (recommended >65 years), CHADS2 score ≥1 2. patients with non-valvular atrial fibrillation 3. unsuitable for long-term warfarin anticoagulation – documented history of bleeding (gastrointestinal, cerebrovascular, etc.) and bleeding tendency allergic to warfarin anticoagulation poor compliance with long-term warfarin anticoagulation postoperative oral aspirin and clopidogrel as prescribed Gray for at least 3 months