Percutaneous kyphoplasty is a technique in which the vertebral body is punctured through the arch or directly percutaneously under the supervision of imaging equipment, and bone cement is injected to increase the strength of the vertebral body, stabilize the diseased vertebral body, and prevent the vertebral body from collapsing, thus providing pain relief and tumor control. In 1990, the technique was further used for the treatment of myeloma, metastases, osteoporotic fractures, etc. In 1994, American scholars Garfin et al. first proposed percutaneous vertebral body kyphoplasty, PKP is based on PVP, first using a balloon to expand the collapsed vertebral body, pushing out the adjacent bone to create a space in the vertebral body, and then injecting bone cement to restore the height of the vertebral body and increase the strength of the vertebral body etc., which serves to relieve or alleviate pain and other effects. In recent years, with the deepening of the understanding of the treatment mechanism, clinical efficacy and complications of PVP and PKP and the upgrading of interventional equipment, PVP and PKP techniques have also been improved and developed. Currently, PVP technology is widely used in clinical practice, and its value is generally recognized, especially in Europe and the United States. Since 2003, the Department of Interventional Radiology of Yantai Yuhuangding Hospital has been carrying out PVP and PKP earlier in China, and has achieved good clinical efficacy, and gradually applied to the treatment of bone metastases other than vertebral body, and has also achieved good therapeutic results. The analgesic and tumor control effects of PVP and PKP are related to the following aspects: ① Bone cement has obvious thermogenic effect in the polymerization stage, especially in the sclerosis stage, up to 82℃, and this thermogenic effect can cause necrosis of some adjacent nerve endings, thus producing analgesic effect. At the same time, the high temperature greater than 70℃ can inactivate the tumor cells in the lesion. ②It increases the strength of the vertebral body, especially PKP obviously restores the height of the vertebral body, improves the stability of the vertebral body, reduces the compression symptoms and avoids the appearance of new subtle fractures. ③The mechanical compressive effect produced by the injection of bone cement partially or completely cut off the blood supply to the tumor, thus accelerating the necrosis of the tumor tissue. ④The toxic effect of the monomer of bone cement damages the nerve endings, thus relieving pain by decreasing the sensitivity of the nerve endings and also inactivating the tumor cells. The advantages of PVP and PKP are as follows: (1) percutaneous puncture does not require open surgery, which is less invasive, and the puncture needle can be inserted into the vertebral body. (3) The efficacy of the treatment is certain, and the patients’ low back pain is significantly reduced or disappeared within a few days after the operation, and the efficacy can be maintained for a long time. The results suggest that vertebroplasty is effective for low back pain caused by vertebral compression fractures in the elderly, and can restore the mobility of the elderly as soon as possible. It is also effective in controlling vertebral metastases and bone metastases from other sites. Therefore, PVP and PKP are suitable for elderly people with osteoporotic vertebral compression fractures, vertebral hemangioma, vertebral metastases, myeloma, and bone metastases in other parts of the body. Patients who need this treatment should contact us for a consultation, thank you.