Professor Chen Xiangjun is one of the first batch of famous TCM doctors in Shanghai and the instructor of the third batch of famous old TCM doctors’ academic experience succession class in China. He has long been engaged in TCM diagnosis and treatment of rheumatic diseases, as well as teaching and scientific research work, and is rich in learning and experience. The author has been following his teacher for more than ten years, and has a brief glimpse of his experience in treating rheumatism, and his experience in treating lupus nephritis (hereinafter referred to as LN) is summarized as follows for the benefit of his colleagues. LN is the most common visceral damage and one of the main causes of death in SLE, and its treatment is more difficult than that of general nephritis and prone to recurrent attacks. Clinical symptoms such as proteinuria, lumbar pain, weakness and swelling are common and can be attributed to the chapters of edema, lumbar pain and deficiency labor in the literature of the past generations, respectively. She believes that LN predominantly occurs in young women, suggesting that it is related to congenital deficiency of kidney energy. If the water-dampness does not transform, the swelling will continue to be difficult to subside, and if the essence flows down, the edema will be persistent and difficult to be cured. Patients often have fever, erythema, swollen and painful joints, burning urine and other heat symptoms on top of the lumbar weakness and foamy urine caused by the deficiency of the spleen and kidney. The cause is either internal dampness and heat caused by spleen deficiency, which is transmitted down to the bladder and kidney, forcing the discharge of essence and blocking water channels, resulting in edema; or internal deficiency of kidney yin and heat, forcing the discharge of essence, resulting in lumbar acidity and proteinuria. Therefore, the clinical evidence is mostly mixed with deficiency and reality, with spleen and kidney deficiency as the basis and damp heat or deficiency heat as the standard. The specific application of the method of tonifying the kidney and fixing the essence in the treatment of LN (1) Basic treatment – benefit the qi, tonify the kidney and fix the essence Lupus nephritis will show proteinuria regardless of edema, and the urine protein is mainly albumin. Albumin is the essence of the human body and is part of the essence, which is transferred by the spleen to promote clearness and the kidneys to seal it. Su Wen? The “Shanggu Tianzhen” said: “The kidney is the main water, receiving the essence of the five viscera and six bowels and hide it”. Zhang Jinyue cloud: “essence to yin liquid, from the twelve organs of biochemical …… hidden in the kidney.” Therefore, the formation of proteinuria is closely related to the spleen and kidneys, especially the kidneys. If the kidney is sufficient, the essence will be guarded internally, but if the kidney is deficient, the essence will not have the right to be collected, and the essence will leak out and form proteinuria. Long-term proteinuria is related to the deficiency of spleen and kidney qi and the lack of power of consolidation. The pathogenesis is the deficiency of spleen qi, the failure of clear qi to rise, the mixing of clear and turbid, and the downward injection of essence, or the deficiency of kidney qi, the deficiency of both yin and yang, the failure of sequestration, and the leakage of essence. In clinical practice, for lupus nephritis with persistent proteinuria as the main manifestation, Dr. Chen firstly emphasizes on strengthening the spleen qi and tonifying the kidney qi, and secondly requires the method of fixing the essence and astringing the essence. Clinically, the patient also shows signs of deficiency of both spleen and kidney essence and qi: white face and spontaneous sweating, tiredness and weakness, deficient and floating face, or with swollen limbs, or even thoracic fluid and ascites, loss of appetite, loose stools, soreness and weakness of the waist and knees, frequent nocturnal urination, loss of libido, pale and fat tongue with tooth marks, thin white and clear moss, weak pulse, and sunken and weak ulnar pulse. Treatment to strengthen the spleen and benefit the qi is mostly used raw astragalus, prince’s ginseng, atractylodes, raw rice kernel, Chinese yam, poria, poria, gorgonian, lotus meat; tonifying the kidney qi is preferred to use black material beans, dogwood, raw earth, cuscuta, cherry seeds, wolfberry; fixing sperm and astringent sperm is mostly used puzzle nut, mulberry cuttlebone, lotus root, corn husk. (2) Nourishing Yin and clearing heat, subduing deficient Yang Patients with lupus nephritis often suffer from Qi deficiency and essence deficiency, and at the same time, due to heat and toxicity disturbance in the body or deficiency of Yin and essence for a long time, Yin does not control Yang, which may be accompanied by Yin deficiency and fire or deficiency of Yin in the liver and kidney at the bottom and deficiency of Yang at the top. sweating, dizziness, dizziness, dizziness, tinnitus, hair loss, red tongue with little moss, thin pulse, etc. In this case, the basic treatment for SLE advocated by Master Chen should be followed: nourishing the liver and kidneys, clearing heat and detoxifying the toxin, and for those with obvious hyperactivity of liver and yang, the method of nourishing yin and submerging yang should also be used. For nourishing the liver and kidney, Liu Wei Di Huang Wan is the basic formula; for clearing heat and detoxifying the toxin, Chen Shi likes to use Shui Niu Jiao, Dan Pi, Red Peony, Snake Tongue Herb, Artemisia annua, Xuan Shen and Fu Ling; for clearing deficiency heat, Zhi Mu, Huang Bai, Di Bone Bark and Yin Chai Hu are used; for subduing liver yang, Dragon Bone, Oyster, Hooked Vine, Stone Cassia, Mother of Pearl, White Peony and Niubizi are used. (3) Benefit qi and warm yang, resolve blood stasis and reduce swelling Although most patients with lupus nephritis belong to the qi and yin deficiency type, patients with advanced lupus nephritis, especially those with combined renal insufficiency, can also have yin deficiency and yang deficiency, and have the type of deficiency of both yin and yang, poor qi and blood flow, and blockage of water channels. The clinical evidence shows that the patient is tired and cold, with cold limbs and hair loss, white face, swelling, abdominal fullness, shortness of breath when moving, not thinking about eating and drinking, short urine, loose stools, light fat tongue or teeth marks, thin white tongue coating, and sunken and fine pulse. At this time, it is necessary to warm the Yang Qi of the heart and kidneys, activate blood circulation, resolve blood stasis, and reduce water retention and swelling. The doctor uses Astragalus membranaceus, Rhizoma Atractylodis Macrocephalae, Radix et Rhizoma Polygonati, Cistanches, Bacopa monniera, Semen spleen, Semen cuscutae, etc. to invigorate blood circulation and eliminate blood stasis; the doctor likes to use Zelenia, Achyranthes bidentatae, Semen A, leeches, ground turtle worms, safflower, peach kernel, rhubarb, motherwort, etc. to promote water retention and reduce swelling; the doctor uses Poria, Poria, Zelenia, melon skin, ginger skin, plantain, etc. Under the guidance of the principle of tonifying the kidney and consolidating essence method, we completed the clinical and experimental research on the treatment of LN with the formula of tonifying the kidney and consolidating essence in the doctoral program of the Municipal Education Commission in 2002. In the clinical part, 59 patients with LN were divided into the treatment group (37 cases) with the formula of tonifying the kidney and consolidating essence plus hormone and the control group (22 cases) with hormone alone, and observed the changes of Chinese medicine symptoms and 24-hour urine protein, serum anti-ds-DNA antibody, complement C3 and C4, blood routine, urine routine, liver and kidney function before and after treatment. In the experimental part, BXSB spontaneous lupus mice were randomly divided into hormone group, kidney tonic formula group, kidney tonic formula combined with hormone group and model group without drugs, and immunohistochemical methods were applied to observe the positive expression of MMP-2, TIMP-2 and Col-IV in the kidney of mice, immunofluorescence to observe IgG deposition, as well as HE staining to observe renal histopathological changes The serum anti-ds-DNA antibody level was measured by ELISA, and urine protein quantification was measured by Kemas Brilliant Blue G250 method. After 3-6 months of treatment, the clinical symptoms such as irritable fever, facial flushing, erythema, lumbago and weakness were significantly improved in the treatment group, while the formula could reduce the patients’ 24h urine protein, blood sedimentation and serum creatinine, anti-dsDNA antibody level and improve C3 level, with better efficacy than the control group, and the hormone dose was significantly less than that of the control group, which could also reduce the complications and side effects. The results of animal experiments also showed that this formula could reduce the expression of TIMP-2, promote the expression of MMP-2, reduce the deposition of Col-IV, reduce the deposition of IgG, reduce the urine protein quantification and serum anti-dsDNA antibody level in the kidney tissue of mice with BXSB lupus, and improve the inflammatory lesions in the kidney tissue, in which the effect of the combination of Chinese and Western medicines was better than that of the hormone and traditional Chinese medicine groups alone. This suggests that the tonic formula has a synergistic effect with hormone, which can improve the clinical symptoms and clinical biochemical and immune indexes of LN patients and facilitate the withdrawal and reduction of hormone. The mechanism of action may be through regulating the expression of MMP-2/TIMP-2, regulating matrix metabolism and reducing collagen aggregation, thus playing a role in protecting the kidney.