Omeprazole should not be taken with certain medicines used to treat heart disease, such as clopidogrel, which may reduce the concentration of medicines used to treat the heart. Omeprazole enteric-coated tablets for reflux esophagitis, gastric and duodenal ulcers, stress ulcers and gastrinoma. Omeprazole enteric-coated tablets common adverse reactions are digestive symptoms, such as nausea, abdominal pain and diarrhea, gastrointestinal flatulence and constipation, neurological symptoms, such as dizziness and headache, somnolence and insomnia, can also be seen in the serum aminotransferase increase. However, the symptoms are mild and may disappear automatically, independent of the dose. Omeprazole enteric-coated tablets are contraindicated in people who are allergic to the product, infants and young children, and people with severe renal insufficiency. Currently there are clinical studies showing that omeprazole and clopidogrel taken together will reduce the antithrombotic effect of clopidogrel due to the simultaneous metabolism of the two drugs by a hepatic enzyme. The above drugs need to be under the guidance of a professional doctor.