Parkinson’s disease is an age-related cerebral neurodegenerative disease. At present, levodopa (L-DOPA) and its compound preparation, anticholinergics, thalamic destruction and other methods are used in clinical treatment. Since June 2009, the author has been treating Parkinson’s disease with needle knife as a tool and the back of the neck as a treatment point according to the principle of needle knife medicine, and the therapeutic effect is remarkable. The typical cases are reported as follows. 1.Summary of medical records Case 1, female, 68 years old, Rojania Brasov city, July 15, 2009, consultation. She presented on July 15, 2009 with a complaint of tremor of the left upper limb, accompanied by head shaking at rest, for more than two years. Two years ago the tremor of the left hand with the left upper limb started, the tremor of the left hand being the most severe. About one year later, she developed head shaking at rest and was diagnosed with Parkinson’s disease at a local hospital. On examination, the left cervical 2-4 articular synovial joint was found to be indurated (+). Impression: Parkinson’s disease (local diagnosis). Disposition:Neck needle knife soft tissue release (Figure 1). Between July 15 and September 29, 2009 this patient was treated 12 times. Generally, the patient was treated once every 5-7 days, and the site was routinely sterilized with iodine povidone-iodine (the same as below). On November 25, 2009, when the patient came to our medical center to see the author, the author met the patient and told him that the tremor of the left hand and left upper limb as well as the shaking of the head had disappeared with a big smile on his face. Example 2: Male, 64 years old, from Trgumulesh, Romania, presented to the clinic on July 26, 2009, complaining of tremor in both hands, and a tremor in the left upper limb. He presented on July 26, 2009 with complaints of tremor in both hands and unresponsiveness for more than 4 years, which had worsened significantly over the past year. The history of the patient was that he started to experience tremor in both hands 4 years ago, and his slow reaction gradually worsened, accompanied by memory loss, and he felt that his memory had decreased significantly, and that he walked with a forward lean and small gait, which had worsened significantly over the past year. She was diagnosed with Parkinson’s disease and Alzheimer’s disease in a local hospital. Physical examination: dull expression, slow movement, hands shaking when unbuttoning clothes; bilateral cervical 2-5 articular synovial joints induration (++), bilateral scapularis scapularis attachment point induration (+). Impression: Parkinson’s disease (follow local diagnosis). Disposition:Needle knife release of the neck (Figure 2). From July 26, 2009 to November 16, 2009, the patient was treated for a total of 9 times. When he came for treatment for the second time, he felt that his mind was clearer than before the treatment, and after the fourth treatment, he felt that the tremor of his hands had been significantly reduced, and he reported that his brain reaction was flexible, his memory had significantly improved, and his forward tilt in walking had disappeared. Case 3, male, 72 years old, from Brasov, Romania, presented to the doctor on December 4, 2009, complaining of head and upper extremity tremor. He presented on December 4, 2009 with a complaint of tremor of the head and upper limbs for more than 15 years. The history of the disease is that the patient was treated with vascular medication in 1994 in Bucharest, and the tremor disappeared in the head and upper limbs. 3 years later, the patient suffered a relapse of the disease, and now he has tremor in the head and upper limbs and weakness in the right hand. Oral treatment for Parkinson’s disease was ineffective. Physical examination: bilateral cervical 2-6 articular synovial joint induration (++). Impression: Parkinson’s disease. Disposition:Cervical needle knife release surgery (Figure 3). On December 9, 2009, she reported that it was easier to turn her head from side to side, but before treatment it was very difficult to turn her head from side to side; on December 14, 2009, she felt that her neck was easy, and her lower limbs were warm, but before treatment her lower limbs were cold, mainly the toes of the feet; on January 8, 2010, she reported that the angle of neck flexion was increased, the lower jaw was able to touch the chest, the angle of turning her head from side to side was increased, and the tremor of the head and the upper limbs was reduced, and the amplitude of the tremor became smaller. The tremor of the head and upper limbs was reduced and the tremor amplitude became smaller. Case 4, male, 55 years old, from Bucharest, Romania, presented on December 4, 2009, complaining of tremor in both hands for 4 years. He presented on December 4, 2009 with complaints of tremor in both hands for more than 4 years and neck discomfort in forced flexion position for more than 8 months. History: Tremor in both hands for 4 years, diagnosed as Parkinson’s disease in the local hospital; in April 2009, she cut branches at home for 2 days, after which she had difficulty in lifting her head, i.e., forced flexion of the neck. Physical examination: extensive stiffness of the neck muscles (++), forced cervical flexion. Impression: Parkinson’s disease. Disposition: Needle-knife release of the neck (Figure 4). On December 11, 2009, she returned to the clinic and reported that she felt relief in her neck for 3 hours on the day of treatment, and since then, she has continued to feel the same way as before. On January 16, 2010, she returned to the clinic and reported that her neck was relieved and the tremor of her hands was reduced within 4 or 5 days after the needle knife release. On January 23, 2010, she returned to the clinic and reported that her neck was relieved and the tremor of her hands was significantly reduced. On January 30, 2010, she returned to the clinic and reported that her sleep was significantly improved, and that her hands trembled once or twice a day before the treatment. On March 6, 2010, she felt that her right hand was basically free of tremor, and on March 13, 2010, she felt that her right hand was trembling again, but the tremor was significantly reduced compared with that before the treatment. Case 5, male, 74 years old, from Brasov, Romania, presented on March 10, 2010 with a complaint of tremor in both hands for 5 years. He presented on March 10, 2010 with complaints of tremor in both hands for more than 5 years and low back pain with bilateral lateral buttock pain for more than 2 years. The history of the patient was that he started to feel tremor in both hands 5 years ago and was diagnosed with Parkinson’s disease locally; he had low back pain for more than 2 years, and in the last year he had pain from the lumbar region to the lateral aspect of both buttocks. Physical examination: bilateral C2-5 synovial joint stiffness (+); thoracic 2-3 spinous processes on both sides of the pressure pain (+). Impression: ① Parkinson’s disease; ② thoracolumbar fascial injury. Disposition: Neck needle knife release surgery (Figure 5). On March 17, 2010, the patient returned to the clinic and reported that the tremor in both hands had decreased, and the pain from the lumbar region to the lateral aspect of the buttocks had decreased. On March 24, 2010, the patient returned to the clinic and reported that the tremor in both hands had decreased, and that the tremor in both hands was still there even though the patient took medication every day before the treatment, but the medication was discontinued and the tremor in both hands appeared once every other day. The pain from the waist to the outside of both buttocks basically disappeared. 2.Treatment 2.1 Treatment principle: Reduce the swelling and pressure, and loosen the pressure and pain of the soft tissues of the back of the neck, nodules, cords and other positive reaction points. 2.2 Specific method Adopting high back chair, sitting back and flexing the neck position or prone position, the patient’s forehead is put on the back of the high back chair or the overlapping foreheads of both hands are put on the back of the hands. 2, 3 cervical spinous treatment point 2 cervical spine is the biomechanical meeting point of the entire spine, due to trauma or strain injury to the muscles, fascia, tendon membranes and other soft tissue damage to the cervical spine instability, such as the head, face and five senses of the disease, to cervical 2 spinous deviation and spinous sides of the pressure and pain as common. 2, 3, 1 fixed point in the cervical 2 spinous process on both sides of the needle knife, general spinous process on both sides of the treatment point from the posterior midline aside 1, 5-2 cm. 2, 3, 2 into the direction of the needle Knife line parallel to the longitudinal axis of the human body, the needle body and the posterior mid-sagittal plane at an angle of about 45 °. 2, 3, 3 into the direction of the needle knife and the human body parallel to the vertical axis, needle body and the posterior mid-sagittal plane. 2, 3, 3 into the depth of the needle knife and the degree of loosening rapid stabbing into the skin in layers of slow loosening, peeling, into the depth of the needle according to the individual, generally in 1-3 cm. according to the feeling under the needle to grasp the needle knife (Fig. 6) loosening, peeling and the depth of the situation, can be up to the surface of the bone (not absolute), loosening peeling can often be based on the sound of the needle knife under the loosening of the loosening, peeling to determine the situation of the normal tissues, no sound or sound is very small, adherence, Normal tissues have no sound or very little sound, while adhesions, scars and other diseased tissues with a high degree of fibrosis will have a loud sound and a high pitch when they are loosened or peeled. In general treatment, 2-3 needle cuts are used for loosening, but if there is a feeling of tightness and hardness under the needle cutter, and the sound of loosening and peeling is loud and high, then the needle cutter loosening can be used for 3-8 needle cuts. 2, 3, 4 Note: Cervical 2 spinous processes are often skewed, needle knife treatment should be based on the specific situation of cervical 2 spinous processes comprehensive analysis, the 2nd cervical vertebrae spinous processes is the meeting point of the force, spinous processes on both sides of the head after the large rectus muscle and the head of the starting point of the oblique muscle, spinous processes bifurcation of the cervical spine is a half-spinous point of adhesion, the part of the head to grasp the good to be able to treat a lot of head, face, the five senses, such as the difficult diseases. 2,4 Neck articular joints 2,4,1 Fixed point 1,5-3 cm away from the posterior median line 2,4,2 Needle direction The knife line is parallel to the longitudinal axis of the human body, and the needle body and the posterior median sagittal plane at an angle of about 45 °, i.e., at an angle of 90 ° with the skin of the point of insertion. 2,4,3 Depth of needle insertion and degree of release The depth of the needle insertion depends on the individual, usually 3-5 cm, and can reach the bone surface or the articular capsule of the articular eminence. The degree of release is the same as above. 2,4,4 Precautions The range of application, the angle of needle insertion and the depth of needle insertion should be strictly selected. Due to the difference in fatness and thinness of the patients, sometimes the No.4 needle knife can not reach the bone surface, but the therapeutic effect is also ideal. Therefore, it is not necessary to force the treatment to the bone surface. 2.5 Thoracic spine treatment point Thoracic 1-5 articular synapses and spinous process point (the same as the cervical spinous process point into the needle depth of 1.5-2.5 cm, the degree of relaxation is the same as above). 2,5,1 Fixed point 1,5-2,5 cm from the posterior midline. 2,5,2 Needle direction The knife line is parallel to the longitudinal axis of the human body, and the needle is perpendicular to the skin of the piercing site. Depth of needle insertion and degree of relaxation: the depth of needle insertion is generally 3-8.5 cm, and the degree of relaxation is the same as above. 2,5,3 Precautions Doctors without experience in needle knife treatment, do not have to force to the bone surface, the general efficacy of the same ideal, individual patients have differences. 3, Discussion Parkinson’s disease is a common neurodegenerative disease in middle-aged and elderly people, mainly characterized by the degeneration of the nigrostriatal pathway, and most of them develop after 60 years old. The main manifestations are tremor of the patient’s hands and feet or other parts of the body, slow movement and stiffness of the body. 1817 British physician, Dr. Jennifer Parkinson, described these symptoms in a paper called “Essay on the Shaking Palsy” (Essay on the Shaking Palsy): slowness of movement, rigidity of the muscles, trembling of the limbs, dragging of the pace, depression and dementia, etc. At that time, it was not yet known that the disease should be categorized as a neurodegenerative disorder of middle and old age. At the time, it was not known which category the disease belonged to, so it was called “tremor palsy”. Parkinson’s disease is the fourth most common neurodegenerative disease in the elderly, affecting 1% of people aged ≥60 years and 0.4% of people aged >40 years. The disease can also develop in childhood or adolescence. The cause of Parkinson’s disease remains unclear. Current research favors a combination of factors related to ageing, genetic factors, and environmental factors. The pathophysiologic changes are the degeneration of nigrostriatal dopaminergic neurons, which leads to a lack of dopamine in the brain, resulting in the relative excitability of the nucleus accumbens and caudate nucleus and causing Parkinson’s disease. The authors believe that the lack of dopamine synthesis in the substantia nigra in Parkinson’s disease is directly related to the blood supply in the brain. Dopamine synthesis and metabolism in the brain exists in several DA pathways, the most important is the nigrostriatal pathway. Spin tyrosine is converted to L-DOPA by intracellular tyrosine hydroxylase (TH) and then to DA by dopa decarboxylase (DDC), which acts through the nigrostriatal tract in the substantia nigra of the chitin nucleus and the caudate nucleus, and is finally broken down into homovanillic acid (HVA) by monoamine oxidase (MAO) (neuronally), catechol-oxygen-methyltransferase (COMT) (glially). ). In other words, the raw material for dopamine synthesis comes from the blood stream, and the lack of the raw material for synthesis is the main reason why dopamine cannot be synthesized. The blood supply to the midbrain and substantia nigra comes from the middle cerebral artery, which is the direct continuation of the internal carotid artery, one of the main arteries of the brain. The nerves innervating the internal carotid artery come from the upper cervical sympathetic ganglion, and the anterior cerebral artery plexus and the middle cerebral artery plexus are all formed by branches of the internal carotid artery. The blood supply of the middle cerebral artery is influenced by the superior carotid sympathetic ganglion. Therefore, the factors that can cause neck lesions may directly or indirectly cause the excitability of the superior carotid sympathetic nerve, thus causing the blood supply of the middle cerebral artery downstream. It is also possible to cause the raw material for synthesizing dopamine, i.e., insufficient blood supply. Dopamine insufficiency is the result of the indirect cause of insufficient blood supply to the middle cerebral artery, while the direct (main) cause is the result of soft tissue injuries, such as the neck myofascia. From the anatomical characteristics of the neck can be seen is that the neck is the bridge between the brain and the trunk, is the hub of the head and the body, the neck muscle stratification is more (head after the large rectus muscle, head after the small rectus muscle, the upper head oblique muscle, head under the oblique muscle, the cervical multifidus muscle, the cervical piriformis muscle, the head of the longest muscle, anterior, middle, posterior oblique muscle, scapulae lifting muscle, cervical semispinalis, head semispinalis, the head of the clamping muscle, the neck of the clamping muscle and the trapezius muscle), the muscles wrapped in the fascia are also the influence of the muscle tissue. Fascial wrapping of the muscles also affects the venous return of the muscular tissues. The venous return of the jugular veins directly affects the venous return of the brain. Both nerves and blood vessels enter and exit the muscle tissue diagonally through the tissue wall, which is made up of dense connective tissue that is part of the fascia, the deep fascia. It is the intermediate membrane of the deep fascia, which is an extremely complex part of the deep fascia, located between the inner and outer layers of the deep fascia. The intermediate membrane separates and surrounds muscles, muscle groups, glands, and large vascular nerve trunks, forming fascial septa, muscle intervals, fascial sheaths, fascial sacs, and vascular nerve sheaths, etc. The intermediate membrane is a very complex part of the deep fascia, located between the inner and outer layers of the deep fascia. Myofascial and other soft tissue injuries have a feature that is often not taken seriously by the clinic, that is, myofascial and other soft tissue injuries caused by the “tablecloth effect”, that is, at one point of application of force (point of injury) can be caused by the application of force (point of injury) the distal end of the fascia and other tissues of the pull, which may result in the injury of this myofascial and other soft tissue injuries, and cause the other part of the fascia and other tissues of the injury. This may cause the soft tissues such as muscle fascia to be pulled, which may cause the nerves and blood vessels in the non-injured area to be pulled or compressed, resulting in a change in the conduction velocity of the nerves (faster or slower), and the diameter of the blood vessels to be thinned and the flow rate to be changed (faster or slower).