Parkinson’s disease is a common degenerative disease of the central nervous system among middle-aged and elderly people, with motor symptoms such as involuntary tremor of the limbs at rest, muscle tonus, bradykinesia, and postural balance disorders, which in the late stage can lead to patients being unable to take care of themselves. Moreover, the non-motor symptoms of Parkinson’s disease, such as psychological problems such as depression and anxiety, also bring a greater burden to patients and their families. The motor complications induced by long-term, high-dose use of levodopa also make the treatment of the disease more complicated. Parkinson’s disease patients who are generally prone to insomnia are often accompanied by anxiety problems. Parkinson’s disease patients gradually appear depression and anxiety, how to do? I. Introduce relevant knowledge of the disease for the patients and help the patients to recognize the causes, manifestations, treatments and rules of the disease they are suffering from. Inform the patients about the treatment, medication and general knowledge about the disease, so that they can understand the condition and cooperate with the treatment. Second, in addition to reasonable medication, need the care and love of family and friends, take the initiative to communicate with the patient, for them to establish a pleasant atmosphere of work and life, so that patients feel relaxed. Third, family members should actively encourage patients to take the initiative to exercise, such as eating, dressing, washing, etc., do not do everything for the patient; for those who have language barriers, the patient can look in the mirror and try to practice pronunciation out loud to reduce the harm of Parkinson’s disease. Fourth, encourage patients to go out and learn about the outside world. It is also a good choice to regain hobbies that are good for the body and mind. Fifth, for the long-term disease, depression, anxiety patients, psychological scale assessment, the score is higher patients, should be given antidepressant, anxiety treatment. Patients should be actively encouraged to create a favorable environment for treatment and recuperation.