The treatment of severe pancreatitis includes non-surgical treatment and surgical treatment. 1. Non-surgical treatment (1) Gastrointestinal decompression: patients need to fast, in addition, gastrointestinal decompression can reduce abdominal distension and prevent vomiting. (2) Prevention and treatment of shock: patients need to replenish fluids, correct acidosis and maintain circulatory stability. (3) Analgesia: Pethidine can be used to relieve severe abdominal pain. (4) Inhibition of pancreatic secretion: proton pump inhibitors (e.g., omeprazole) or H2 receptor blockers (e.g., ranitidine), can indirectly inhibit pancreatic secretion. Growth inhibitors and growth inhibitor analogs (e.g. octreotide) also inhibit pancreatic secretion. (5) Nutritional support: during the fasting period, parenteral nutrition should be carried out, and enteral nutrition can be given after the recovery of intestinal function. (6) Antibiotics: such as third-generation cephalosporins (e.g., cefixime) + anti-anaerobes (e.g., metronidazole), quinolone (e.g., levofloxacin) + anti-anaerobes. 2. Surgical treatment: the most commonly used is necrotic tissue removal plus drainage. The indications are secondary infection of the pancreas and peripancreatic necrotic tissue, combined with intestinal perforation, hemorrhage, pancreatic pseudocyst, accompanied by obstruction of the lower part of the common bile duct or biliary tract infection. Patients with severe pancreatitis should not self-medicate and should go to the hospital as soon as possible for standardized treatment under the guidance of a doctor.