The most common causes of morning stiffness are rheumatic system diseases, such as rheumatoid arthritis and ankylosing spondylitis. It can also be seen in some orthopedic diseases, such as carpal tunnel syndrome, tendon sheath cysts and so on. Morning stiffness is mainly characterized by stiffness and swelling of the joints in the morning, limitation of activities, and gradual reduction after activities. The most common disease is rheumatoid arthritis. It can be manifested as swelling of the joints of both hands in the morning, limitation of fist making, lasting more than one hour, and the symptoms gradually improve after activities. Other rheumatic diseases, such as ankylosing spondylitis and osteoarthritis, can also occur, and the severity and duration of symptoms are related to disease activity. In addition to rheumatic diseases, some orthopedic diseases such as carpal tunnel syndrome, tendon sheath cysts, etc., can also appear morning stiffness, mainly due to trauma, improper bandaging, etc. caused by high pressure in the carpal tunnel, nerve entrapment, thus causing morning stiffness. If morning stiffness occurs, it is necessary to go to the rheumatology and immunology department or orthopedics department of the hospital in time to clarify the specific causes of morning stiffness, in order to get targeted treatment.