Parkinson’s disease is a common neurological disorder of the middle-aged and elderly, and was first described systematically by the British physician James Parkinson. Parkinson’s was first described systematically by the British internist James Parkinson, who did not know what category of disease it should be classified as and called the disease “tremor palsy”. This name was also used in our old textbooks, and is still used by some non-specialists today. Later, the disease was observed more carefully and it was found that in addition to tremor, there were other symptoms such as muscle stiffness and smaller and smaller writing, but the strength of the muscles of the limbs was not impaired, so it was suggested that the disease be named “Parkinson’s disease. The disease generally begins to develop at the age of 50 to 65, the incidence increases gradually with age, and the incidence rate is 0.1% in the overall population, and the incidence rate is about 1% over the age of 50, and there are about 2 million people suffering from this disease in China. Data show that the incidence of Parkinson’s disease is slightly higher in men than in women. Parkinson’s disease is characterized by tremors, rigidity, and slow movements. In recent years, there is a trend toward younger people with Parkinson’s disease, with the APDA calling people younger than 40 years old young people with Parkinson’s disease. The exact cause of Parkinson’s disease remains unclear. Scientific studies tend to link it to a combination of ageing, genetic susceptibility and exposure to environmental toxins. 1. Ageing: 2. Environmental factors: Epidemiological findings have revealed regional differences in the prevalence of Parkinson’s disease, so it is suspected that there may be toxic substances in the environment that damage neurons in the brain. 3, family heredity: medical doctors in long practice found that Parkinson’s disease seems to have a tendency to gather in families, and families with Parkinson’s disease have a somewhat higher incidence of their relatives than the normal population. 4, genetic susceptibility: Although the occurrence of Parkinson’s disease is related to aging and environmental toxins, not all elderly people or people exposed to the same environment, or even people who also smoke large amounts of MPTP will develop Parkinson’s disease. Although there is also a familial clustering of Parkinson’s disease patients, no clear causative gene has been found in disseminated Parkinson’s disease patients to date, suggesting that the etiology of Parkinson’s disease is multifactorial. In summary, no single factor can fully explain the etiology of Parkinson’s disease. Most researchers prefer that the etiology of Parkinson’s disease is the result of a combination of the above-mentioned factors. That is, after middle age, individuals who are susceptible to environmental toxins develop subclinical nigrostriatal damage after exposure to toxins due to their detoxification dysfunction, which worsens with age, and dopaminergic neurons progressively continue to die and degenerate, eventually losing compensation and developing clinical symptoms of Parkinson’s disease.