Currently, the incidence rate of breast cancer in China is generally below 1 in 10,000. However, in big cities where the lifestyle changes a lot, the incidence rate of breast cancer reaches about 28 to 40 per 100,000. The reason for the prevalence of breast cancer in cities is not only due to the change of diet structure, but also due to the stressful pace of work and life of urban women. As these women are prone to depression, such as tension and anxiety, loneliness and depression, sadness and sorrow, bitterness and disappointment, impatience and irritation, the body’s life rhythm is disturbed and the neuroendocrine system is dysfunctional, which leads to the imbalance of the internal environment and the decrease of immunity, which can reduce the production and release of thymosin from the thymus gland, and the ability of lymphocytes and macrophages to monitor and phagocytose mutated cells in the body. The ability of lymphocytes and macrophages to monitor and phagocytose mutated cells in the body decreases, making them prone to cancer, especially breast cancer. Researchers at the Johns Hopkins School of Public Health studied 2,017 subjects to determine if depression and cancer were related over a 13-year period. The study found that patients with major depression were more likely to develop breast cancer compared to other women. The researchers believe depression may be responsible for the hormonal changes that trigger certain cancers. Depressed patients are prone to refuse treatment Italian researchers found that only 51 percent of depressed patients chose chemotherapy after breast removal, while 92 percent of women without depression chose chemotherapy after surgery. In response, researchers say women with depression are more likely to refuse chemotherapy after breast cancer surgery, a move that can push them to the brink of death. A doctor in Milan said that depression decreases the survival rate of breast cancer patients, so psychiatric support and treatment of depression can greatly improve the rate at which patients receive chemotherapy, and therefore will improve their prognosis.