New approach to pancreatic tumor treatment

The grim status of pancreatic cancer According to the statistics of the American College of Oncology (ACS), since 1990, the incidence and mortality of major malignancies in the United States have shown a decreasing trend, but the incidence and mortality of pancreatic cancer have increased year by year. The National Institutes of Health (NIH) predicts that there will be 46,420 new cases of pancreatic cancer and 39,590 deaths in 2014. The current top malignancy death cases among men and women are: bronchial lung cancer, prostate cancer, colorectal cancer, pancreatic cancer (men); bronchial lung cancer, breast cancer, colorectal cancer, pancreatic cancer (women). In a recent statistical data on pancreatic tumors, the prevalence of pancreatic cancer in Shanghai, China increased from 11.13/105 in 2001 to 17.28/105 in 2009 for men and from 9.91/105 in 2001 to 14.04/105 in 2009 for women. The main incidence age groups were 60 (23.8%), 70 (31.2%) and 80 (36.4%) years old. In this study with a sample size of 846 people, the 1-year, 2-year and 5-year survival rates after obtaining a diagnosis of pancreatic cancer were 35.0%, 14.4% and 4.4%, respectively, with a median survival of 7.8 months. Another retrospective study from the Shanghai Institute of Oncology showed that the incidence of pancreatic cancer in the Shanghai area doubled from 1973 to 2000. Treatment and Treatment Difficulties In the early stage of pancreatic cancer, radical tumor resection with R0 resection (histologically negative tumor cells at the surgical margins) is still recognized as the most effective treatment modality. In the above statistics, the median survival of pancreatic cancer patients who underwent radical surgery versus those who did not was 11.2 months and 5.6 months, respectively, with a p-value < 0.001, a very statistically significant difference. Unfortunately: the overall 5-year survival rate of pancreatic cancer patients has not improved significantly in the last almost 20 years and remains below 5%. This is partly due to the difficulty of early diagnosis of pancreatic cancer: by the time patients are diagnosed, most of them are already at an advanced stage and only less than 20% of them have the opportunity for radical surgery. On the other hand, because the blood supply of the pancreas itself is complex and abnormally rich, and the presence of tumor may change the original normal vascular structure, uncontrollable bleeding becomes a great obstacle for surgeons to successfully perform pancreatic surgery. Advantages of minimally invasive surgery I. The large incision of traditional open surgery is avoided and only four to five 1 cm poke holes are needed to complete the surgery, which saves the abdominal wall nerves and muscles from being cut. Most of the traditional open surgical incisions in abdominal surgery inevitably injure the abdominal wall nerves and tear or sever the abdominal wall muscles, while endoscopic surgery generally does not injure the abdominal wall nerves and muscle damage is minimal because of the small and scattered poke holes. Therefore, the incisional complications of this surgery are greatly reduced or even eliminated, and the incisional pain is mild, and there is no numbness around the incision left by the severed abdominal wall nerves. Second, less organ interference and faster postoperative recovery: lumpectomy or robotic surgery avoids the exposed pulling and drying of organs in the abdominal cavity in the air, which reduces the interference of surgery with the organs in the non-operative area and enables the patient to recover quickly after surgery. Minimally invasive surgery, because there is no friction of the gauze pad on the plasma membrane surface of the organs, no evaporation of water from the visceral surface, no foreign bodies such as operating room dust and talcum powder scattered into the abdominal cavity, no excessive pressure affecting the blood flow of the organs, therefore, its interference with the organs is greatly reduced, and the functional paralysis period of the organs after surgery is greatly shortened, coupled with the fact that postoperative wound pain is light and can be moved to the ground early, the functional recovery of the organs is accelerated, and the chance of organ adhesions is greatly reduced. The chance of organ adhesions is greatly reduced, and postoperative systemic complications such as pulmonary infection and deep vein thrombosis are also greatly reduced. In addition, the magnified images and excellent illumination of lumpectomy and robotic surgery make it quite similar to microsurgery, with more precise dissection and less bleeding.