The American scholar Hasin T et al. included 1922 patients through a case-control study and cohort study design to observe the incidence of cancer in heart failure patients and its prognostic impact. At the beginning of the study, the rates of patients with heart failure and control patients with a history of cancer were 22% and 23%, respectively, and after a mean follow-up time of (7.7 ± 6.4) years, a total of 244 new cancer cases were diagnosed. Patients with heart failure were 68% more likely to develop cancer compared to controls, after adjusting for BMI, smoking, and comorbidities (HR 1.68, 95% CI 1.12-2.5), and the risk of developing cancer increased over time. In patients with heart failure, cancer events increased the risk of death (HR 1.56, 95% CI 1.22-1.99), which was adjusted for age, sex, duration of disease, and comorbidities. Risk ratios were similar in men and women, with a trend toward increased association for age ≤75 years (p=0.22) and for recent cancer diagnosis (p=0.075). (Li J. Abstract) J Am Coll Cardiol. 2013, 62:881-6