Solid pseudopapillary tumors of the pancreas occur mainly in young and middle-aged women. Most of the lesions progress slowly and tend to be large in size when detected. Depending on the patient’s specific condition and test results, different management options are needed, mainly including surgical management as well as palliative care. Imaging is the mainstay of diagnosis of solid pseudopapillary tumors of the pancreas. The vast majority of pseudopapillary tumors are benign and only need close clinical observation; for symptomatic and malignant pseudopapillary pancreatic tumors and those that cannot be identified as benign or malignant in clinical practice, surgical treatment is needed. 1. Surgical treatment: most of the patients need to choose radical resection surgery after the discovery of the lesion, and the surgical treatment options include pancreaticoduodenectomy, pancreatic body-tail resection, and simple lesion removal, which can basically achieve clinical cure after surgical resection. 2. Palliative treatment: patients who are older, with obvious deviation in physical condition and unable to tolerate surgery, can choose to do palliative treatment, and some of them can choose to do local radiotherapy treatment. After the discovery of lesions, from the clinical point of view, should be done as early as possible radical surgical resection, specific circumstances need to be under the guidance of clinicians to do standardized treatment.