Treatment of tuberculosis requires combination, long courses of medication. The type of drug often has to be four or more, and the course of treatment is at least six months, one year, and in some cases two years or more, which brings up a problem – the side effects of anti-TB drugs. In clinical practice, the incidence of side effects is quite high, which requires us to recognize it well and deal with it. I will start with a classification of common drug side effects. When the following side effects occur, the drug must be discontinued. Such as: anaphylaxis, purpura, flu syndrome, high fever, jaundice, acute urinary closure, mental disorder, exfoliative dermatitis, skin rash. Except for mild rashes that can subside on their own, additional anti-allergy medication can be considered for simultaneous observation. Other reactions should not be tried again to prevent other serious and unpredictable side effects. Hepatic impairment: The most common side effect, often manifested as gastrointestinal reactions such as nausea, vomiting, or jaundice, or no reaction. All drugs can cause hepatic impairment, except ethambutol and amikacin, which are essentially non-hepatic. In order of severity (from severe to mild): rifampin, pyrazinamide, isoniazid, sodium para-aminosalicylate, Lautin, levofloxacin, clarithromycin, etc. Liver function aminotransferases are twice as high (glutathione, glutamate normal 40) rifampicin and pyrazinamide must be discontinued, greater than 3 times or jaundice all anti-tuberculosis drugs must be discontinued, while strengthening liver protection therapy. Allergies: Also common, including drug fever, rash, pruritus, and flu syndrome. More severe allergies must be discontinued, and small doses of each drug must be tried after the allergic state is eliminated. Mild allergies can be observed with anti-allergy medications. In most cases, allergies, regardless of their severity, require hospitalization at the direction of a physician, and in many cases, hospitalization for observation. Gastrointestinal reactions: The drugs that can cause are basically the same as liver function damage. However, if the liver function is normal, it is necessary to intensify the antiemetic and anti-gastric treatment, and to consider stopping or changing the medication in severe cases. Peripheral peripheral neuritis: numbness and pins and needles sensation at the end of the extremities. This is mainly due to isoniazid. Consider adding vitamin B6 to counteract it when it occurs. Usually 5-10mg/day. For high dose of isoniazid, it can be increased to 30-100mg. Optic nerve injury: manifesting as vision loss, visual fatigue, eye dryness, foreign body, acidity, blurred vision, poor near reading power, small visual field, poor visual color, etc. It is mainly caused by ethambutol, which can cause irreversible damage and even blindness. When it appears, ethambutol can be stopped immediately and vitamin B6, nicotinamide, and vasodilator drugs can be added, usually in 2-6 months, and gradually recovered. Hearing loss, vestibular impairment, renal impairment: manifested as vertigo, ataxia, and increased renal function indicators, mainly due to streptomycin, amikacin, and capreomycin drugs, which must be discontinued once they appear. Arthralgia: Mostly due to hyperuricemia caused by pyrazinamide, but also due to fascias, which can be reduced by drinking more water to speed up excretion. Reduced blood white blood cells: Severe cases can lead to bone marrow suppression, commonly associated with rifamycin, streptomycin, levofloxacin, etc. Give symptomatic treatment to raise white blood cells. The above are some of the more common side effects of drugs, there are some less common will not be repeated here, write these to let you have some simple understanding of the emergence of side effects in many cases still need to go to the regular hospital treatment and treatment. The point is that in the course of anti-TB treatment, it is important to review regularly, such as monthly blood tests, liver and kidney function, and to deal with the situation in a timely manner to minimize the damage of side effects.